Altitudinal and thermal gradients of hepatic Cyp1A gene expression in natural populations of Salmo trutta from high mountain lakes and their correlation with organohalogen loads
Altitudinal and thermal gradients of hepatic Cyp1A gene expression in natural populations of Salmo trutta from high mountain lakes and their correlation with organohalogen loads
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DOI：
10.1016/j.envpol.2010.01.003
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发表时间：
2010-05-01
影响因子：
8.9
通讯作者：
Pina, Benjamin
中科院分区：
文献类型：
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作者：
Jarque, Sergio;Gallego, Eva;Pina, Benjamin
外源性暴露的生物标志物细胞色素p450 A1（Cyp 1A）被用来分析化学污染在萨尔莫（褐鳟鱼）从9个高山欧洲湖泊在挪威，塔特拉斯，蒂罗尔州，和比利牛斯山脉中部的生物反应。肝脏Cyp 1A mRNA水平与绝对年平均气温的倒数采样湖泊和肌肉浓度的几个疏水性有机卤素化合物（OC），包括氯化多氯联苯（PCB），DDE和DDT。Cyp 1A表达和OC含量之间的相关性在整个温度范围内（-0.7摄氏度和+6.2摄氏度之间）观察到，但也在没有任何热梯度的情况下。我们的结论是，空气中的污染物积累在高山湖鱼的浓度高到足以增加Cyp 1A的表达，在其他可能的影响。由于半挥发性有机碳的地理分布受到气温的强烈影响，未来的气候变化将可能增强其在湖泊生态系统中的生理效应。(C)2010爱思唯尔有限公司保留所有权利。
The biomarker of xenobiotic exposure cytochrome p450A1 (Cyp1A) was used to analyze the biological response to chemical pollution in Salmo trutta (brown trout) from nine high mountain European lakes in Norway, Tatras, Tyrol, and central Pyrenees. Hepatic Cyp1A mRNA levels correlated both with the reciprocal of absolute annual average air temperatures of the sampled lakes and with muscle concentrations of several hydrophobic organohalogen compounds (OC), including chlorinated poly-chlorobiphenyls (PCB), DDE, and DDT. The correlation between Cyp1A expression and OC content was observed across the whole temperature range (between -0.7 degrees C and +6.2 degrees C), but also in the absence of any thermal gradient. We concluded that airborne pollutants accumulate in high mountain lake fish at concentrations high enough to increase Cyp1A expression, among other possible effects. As geographical distribution of semi-volatile OC is strongly influenced by air temperatures, future climate modifications will potentially enhance their physiological effects in lake ecosystems. (C) 2010 Elsevier Ltd. All rights reserved.