Action and object naming in frontotemporal dementia, progressive supranuclear palsy, and corticobasal degeneration
Action and object naming in frontotemporal dementia, progressive supranuclear palsy, and corticobasal degeneration
复制标题
DOI：
10.1037/0894-4105.20.5.558
复制
发表时间：
2006-09-01
期刊：
影响因子：
2.4
通讯作者：
Cappa, S. F.
中科院分区：
文献类型：
--
作者：
Cotelli, M.;Borroni, B.;Cappa, S. F.
据报道，与额颞叶痴呆（FFD）患者的物体命名相比，动作命名受到不成比例的损害。这一发现归因于额叶皮层在动作命名中的关键作用。研究FTD不同亚型以及进行性核上性麻痹（PSP）和皮质基底变性（CBD）相关条件下的客体和动作命名，可能有助于阐明动作-客体差异的大脑相关因素，并为其潜在的认知机制提供线索。结果表明，除语义性痴呆外，所有患者组的动作命名比物体命名受损更严重。这种差异在FTD的额叶变体和阿尔茨海默病患者中也类似，而原发性进行性失语症、PSP和CBD患者在口腔产生动作方面的受损程度明显高于物体。这些发现表明，动作命名障碍不是FFD的一般特征，而是与影响涉及动作知识和动作表征的额顶叶-皮层下回路的条件有关。
Action naming has been reported to be disproportionately impaired in comparison to object naming in patients with frontotemporal dementia (FFD). This finding has been attributed to the crucial role of frontal cortex in action naming. The investigation of object and action naming in the different subtypes of FTD, as well as in the related conditions of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), may thus contribute to the elucidation of the cerebral correlates of the action-object discrepancy as well as provide clues to the underlying cognitive mechanisms. The results indicated that, with the exception of semantic dementia, action naming was more impaired than object naming in all patient groups. The discrepancy was similar in frontal variant of FTD and Alzheimer's disease patients, whereas patients with nonfluent primary progressive aphasia, PSP, and CBD were significantly more impaired in the oral production of actions than of objects. These findings indicate that action naming impairment is not a general feature of FFD, but rather is associated with conditions that affect the frontoparietal-subcortical circuits involved in action knowledge and action representation.