Pharmacokinetics of prednisone and its metabolite prednisolone in children with nephrotic syndrome during the active phase and in remission.
Pharmacokinetics of prednisone and its metabolite prednisolone in children with nephrotic syndrome during the active phase and in remission.
复制标题
泼尼松及其代谢物泼尼松龙在肾病综合征儿童活动期和缓解期的药代动力学。
DOI：
10.1111/j.1365-2125.1984.tb02367.x
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发表时间：
1984
影响因子：
3.4
通讯作者：
A. Martini
中科院分区：
文献类型：
--
作者：
G. Gatti;E. Perucca;G. Frigo;L. Notarangelo;L. Barberis;A. Martini
The kinetics at steady state of prednisone and its metabolite prednisolone were determined in nine nephrotic children during the active phase of the disease and in remission. There were no differences in serum prednisone levels between the two occasions. Prednisone levels were lower than prednisolone levels. Total serum prednisolone levels were significantly lower during the active phase than in remission (AUC: 2452 +/- 207 vs 3392 +/- 293 ng ml-1 h respectively). Half-life values were similar on both occasions. The binding of prednisolone to serum proteins was markedly impaired during the active phase as compared to the remission. Free fraction values correlated positively with total drug concentration. A negative correlation between free fraction and serum albumin level was found during the active phase. Free prednisolone levels during the active phase did not differ significantly from those observed during remission (AUC: 937 +/- 128 vs 847 +/- 81 ng ml-1 h respectively). These data indicate that pharmacokinetic changes are unlikely to be responsible for alterations in steroid responsiveness in nephrotic patients with hypoalbuminaemia.
肾病综合征对儿童泼尼松龙吸收和处置的影响。
DOI：
--
发表时间：
1982
期刊：
The International journal of pediatric nephrology
影响因子：
--
作者：
RocciJr,ML;Assael,BM;Appiani,AC;Edefonti,A;Jusko,WJ
通讯作者：
Jusko,WJ