Recombinant feline viruses containing the myc gene rapidly produce clonal tumours expressing T‐cell antigen receptor gene transcripts
Recombinant feline viruses containing the myc gene rapidly produce clonal tumours expressing T‐cell antigen receptor gene transcripts
复制标题
含有 myc 基因的重组猫病毒可快速产生表达 T 细胞抗原受体基因转录本的克隆肿瘤
DOI：
10.1002/ijc.2910400108
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发表时间：
1987
影响因子：
6.4
通讯作者：
J. Neil
中科院分区：
文献类型：
--
作者：
D. Onions;G. Lees;D. Forrest;J. Neil
我们和其他人最近发现，含有myc基因（FeLV‐myc）的重组猫白血病病毒（FeLV）发生在高达30%的自然发生的T细胞淋巴肉瘤病例中。对两种FeLV‐myc分离株疾病谱的研究表明，它们在短潜伏期后诱导克隆或寡克隆T细胞肿瘤。胸腺肿瘤的表型模式受到限制，因为它们都表达T细胞抗原受体的α和β链，并且可以在不添加外源性白细胞介素-2的情况下在体外培养中容易地建立。尽管辅助FeLV从感染猫传播给未感染的示踪猫，但没有FeLV‐myc病毒水平传播的证据，表明这些病毒在胸腺淋巴肉瘤的个体病例中从头出现。
We, and others, have recently shown that recombinant feline leukaemia viruses (FeLV) containing the myc gene (FeLV‐myc) occur in up to 30% of naturally occurring cases of T‐cell lymphosarcoma. Investigation of the disease spectrum of two FeLV‐myc isolates showed that they induced clonal or oligoclonal T‐cell tumours after a short latent period. The pheno‐typic pattern of the thymic tumours was restricted in that they all expressed the alpha and beta chains of the T‐cell antigen receptor and could readily be established in culture in vitro without the addition of exogenous interleukin‐2. Although helper FeLV was transmitted from infected cats to uninfected tracer cats, there was no evidence of horizontal transmission of FeLV‐myc viruses, suggesting that these viruses arise de novo in individual cases of thymic lymphosarcoma.