Oligoglycines: Materials with Unlimited Potential for Nanotechnologies
Oligoglycines: Materials with Unlimited Potential for Nanotechnologies
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DOI：
10.1134/s1995078008050042
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发表时间：
2008-06-01
影响因子：
0.8
通讯作者：
Chinarev, A. A.
中科院分区：
文献类型：
--
作者：
Bovin, N. V.;Tuzikov, A. B.;Chinarev, A. A.
肽是纳米技术最有前途的分子。即使是最简单的氨基酸甘氨酸也可以合成适合超分子设计的稳定衍生物。寡甘氨酸能够形成一种不寻常的（非规范）结构，即所谓的聚甘氨酸 II，其中肽螺旋 3(1)（Phi= -76.9 度，psi = 145.3 度）与六个相邻螺旋形成氢键网络。线性寡甘氨酸在所谓的二触角、三触角和四触角肽中的支化排列产生了一类新的分子，其特征一方面在于其简单性，另一方面在于有足够的机会自组装成复杂的超分子结构。本文综述了对称前寡甘氨酸的合成、其在平面原子光滑层和囊泡中自组装的研究以及聚甘氨酸II结构在水介质中的组装和分解条件的报道。描述了类似超分子结构在云母表面组装的结构特征和特点。证明了该纳米图案制备过程的可能控制。讨论了在纳米设计中使用此类新型材料的前景。提出了创建新型抗病毒剂的概念，即病毒本身促进其前体形成的超分子化合物。
Peptides are the most promising molecules for nanotechnologies. Stable derivatives suitable for supramolecular design can be synthesized even from the simplest amino acid, glycine. Oligoglycines are able to form an unusual (noncanonical) structure, so-called polyglycine II, where peptide helices 3(1) (Phi= -76.9 degrees, psi = 145.3 degrees) form a network of hydrogen bonds with six neighbors. The arrangement of linear oligoglycine in branched so-called di-, tri-, and tetraantennary peptides gives rise to a new class of molecules, which arc distinguished by their simplicity, on the one hand, and by ample opportunities for self-assembly into complex supramolecular structures, on the other hand. This article summarizes the reports of synthesis of symmetrical ante oligoglycines, studies of their self-assembly in plane atomic smooth layers and vesicles, and conditions of the assembly and disassembly of the polyglycine II structure in an aqueous medium. Structural features and peculiarities of assembly of the similar supramolecular structures on the surface of mica are described. The possible control of this process for preparing nanopatterns is demonstrated. Prospects are discussed for using this new class of materials in nanodesign. The concept of creating a new type of antiviral agents, supramolecular compounds whose formation from a precursor is promoted by the virus itself, is proposed.