IL-1, quo vadis?
IL-1, quo vadis?
复制标题
IL-1，何去何从？
DOI：
10.1016/j.atherosclerosis.2012.03.010
复制
发表时间：
2012
期刊：
影响因子：
5.3
通讯作者：
Latz,Eicke
中科院分区：
文献类型：
--
作者：
Grebe,Alena;Latz,Eicke
脂质和免疫细胞在动脉内膜下空间的积聚称为动脉粥样硬化。这一缓慢但渐进的过程发生在大多数人类身上。动脉粥样硬化直到动脉粥样硬化血管的变化导致血流减少或导致管腔血栓闭塞才能被发现。人们普遍认为血胆固醇水平升高在动脉粥样硬化的发病机制中起着重要作用。然而，为什么动脉粥样硬化病变中过度的脂肪沉积伴随着复杂的炎症反应，人们还知之甚少。大量的细胞因子、趋化因子和其他因素已被证明影响对脂质积聚的炎症反应，其中一些因素可以调节随后的动脉结构变化。
The build up of lipids and immune cells in the subintimal space of arteries is termed atherosclerosis. This slow, but progressive process occurs in the majority of humans. Atherosclerosis remains undetected until changes in the atherosclerotic vessel cause decreased blood flow, or result in luminal thrombotic occlusion.It is generally accepted that elevated blood cholesterol levels play a causative role in the pathogenesis of atherosclerosis. Why the excessive lipid deposition in atherosclerotic lesions is accompanied by an elaborate inflammatory response however, is far less understood. A myriad of cytokines, chemokines and other factors have been shown to influence the inflammatory reaction towards the buildup of lipids and some of these factors can modulate the ensuing architectural changes of the arteries1.