Comparison of Effects of Different Statins on Contrast-Induced Acute Kidney Injury in Rats: Histopathological and Biochemical Findings.
Comparison of Effects of Different Statins on Contrast-Induced Acute Kidney Injury in Rats: Histopathological and Biochemical Findings.
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不同他汀类药物对对比剂诱发的大鼠急性肾损伤的影响比较：组织病理学和生化结果
DOI：
10.1155/2017/6282486
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发表时间：
2017
影响因子：
--
通讯作者：
He B
中科院分区：
文献类型：
--
作者：
Wang XL;Zhang T;Hu LH;Sun SQ;Zhang WF;Sun Z;Shen LH;He B
他汀类药物是预防造影剂诱导的急性肾损伤（CI-AKI）的一种有前途的新策略。在这项研究中，我们比较了不同他汀类药物在CI-AKI大鼠模型中的改善作用。将Sprague-Dawley大鼠分为5组：对照组; CI-AKI组; CI-AKI +瑞舒伐他汀组（10 mg/kg/天）; CI-AKI +辛伐他汀组（80 mg/kg/天）;和CI-AKI +阿托伐他汀组（20 mg/kg/天）。通过脱水72小时诱导CI-AKI，然后在静脉注射低渗造影剂（CM）前20分钟肌内注射呋塞米。他汀类药物在CM注射前连续3天每天一次经口灌胃给药，CM注射后4小时一次。CM注射后24小时处死大鼠，评价肾功能、肾组织病理学、一氧化氮（NO）代谢产物以及氧化应激、炎症和细胞凋亡的标志物。结果表明，阿托伐他汀和瑞舒伐他汀，而不是辛伐他汀改善CM诱导的血清肌酐升高和组织病理学改变。阿托伐他汀和瑞舒伐他汀对CM诱导的氧化应激表现出相似的有效性，但辛伐他汀的有效性较低。阿托伐他汀对NO系统功能障碍和细胞凋亡最有效，而瑞舒伐他汀对炎症最有效。我们的研究结果表明，他汀类药物在预防CI-AKI方面表现出不同的作用，当以等效的降脂剂量给药时。
Statins are a promising new strategy to prevent contrast-induced acute kidney injury (CI-AKI). In this study we compared the ameliorative effect of different statins in a rat model of CI-AKI. Sprague-Dawley rats were divided into five groups: control group; CI-AKI group; CI-AKI + rosuvastatin group (10 mg/kg/day); CI-AKI + simvastatin group (80 mg/kg/day); and CI-AKI + atorvastatin group (20 mg/kg/day). CI-AKI was induced by dehydration for 72 hours, followed by furosemide intramuscular injection 20 minutes before low-osmolar contrast media (CM) intravenous injection. Statins were administered by oral gavage once daily for 3 consecutive days before CM injection and once 4 hours after CM injection. Rats were sacrificed 24 hours after CM injection, and renal function, kidney histopathology, nitric oxide (NO) metabolites, and markers of oxidative stress, inflammation, and apoptosis were evaluated. The results showed that atorvastatin and rosuvastatin but not simvastatin ameliorated CM-induced serum creatinine elevation and histopathological alterations. Atorvastatin and rosuvastatin showed similar effectiveness against CM-induced oxidative stress, but simvastatin was less effective. Atorvastatin was most effective against NO system dysfunction and cell apoptosis, whereas rosuvastatin was most effective against inflammation. Our findings indicate that statins exhibit differential effects in preventing CI-AKI when given at equivalent lipid-lowering doses.