Germinal testicular tumors in childhood. Report of observations and literature review.
Germinal testicular tumors in childhood. Report of observations and literature review.
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儿童时期的生殖睾丸肿瘤。
DOI：
10.1159/000463762
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发表时间：
1984
期刊：
影响因子：
23.4
通讯作者：
R. Stiens
中科院分区：
文献类型：
--
作者：
L. Weissbach;J. Altwein;R. Stiens
对1955~1981年发表的1124例病例观察和45例儿童睾丸肿瘤进行了评价。将年龄分布、组织学(WHO分类)、分期和预后与1,062例成人病例进行比较。诊断程序已逐项列出。治疗方法的优先顺序和各种方法的有效性，取决于分期和组织学，以及毒副作用和其他并发症被记录在案。在儿童中，29%的儿童睾丸肿瘤是非生殖性的，而成人为8%。49%为卵黄囊肿瘤。年龄分布因组织学不同而不同。转移的发生率(9%)低于成人(61%)。传播主要是血源性的。经切除术治愈的畸胎瘤预后最好。卵黄囊肿瘤局限于睾丸，在2岁以下的婴儿中，仅用睾丸切除术就足够了。年龄较大的儿童需要辅助化疗。总体而言，在评估的儿童睾丸恶性肿瘤病例中，有15%的病例选择了化疗。
1,124 case observations, published from 1955 to 1981, and 45 of our own cases of childhood testicular tumor are evaluated. The age distribution, histology (WHO classification), stage and prognosis are compared to 1,062 adult cases. Diagnostic procedures are itemized. Priorities in the therapeutic approach and the effectiveness of various methods, depending on stage and histology, and toxic side effects and other complications are documented. In children, 29% of childhood testicular tumors are non-germinal, as compared to 8% in adults. 49% are yolk sac tumors. The age distribution differs depending on histology. Metastases occur less frequently (9%) than in adults (61%). Dissemination is predominantly hematogenic. Prognosis is best in teratoma which is cured by orchiectomy. Yolk sac tumor limited to the testicle, in infants less than 2 years old, is sufficiently treated with orchiectomy alone. Older children require adjuvant chemotherapy. Overall, chemotherapy was indicated in 15% of the evaluated cases of childhood testicular malignoma.