Metallic zinc exhibits optimal biocompatibility for bioabsorbable endovascular stents.
Metallic zinc exhibits optimal biocompatibility for bioabsorbable endovascular stents.
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DOI：
10.1016/j.msec.2015.07.022
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发表时间：
2015-11-01
期刊：
影响因子：
--
通讯作者：
Goldman J
中科院分区：
文献类型：
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作者：
Bowen PK;Guillory RJ 2nd;Shearier ER;Seitz JM;Drelich J;Bocks M;Zhao F;Goldman J
尽管耐腐蚀裸金属支架通常被认为是有效的，但由于潜在的长期并发症，它们在病变动脉中的永久存在是一个日益公认的限制。我们先前报道，金属锌在小鼠主动脉内表现出理想的生物腐蚀率，从而增加了锌作为血管内支架应用的候选基础材料的可能性。本研究旨在进一步评价金属锌的动脉生物相容性。将金属锌丝穿入大鼠腹主动脉腔内，最长达6.5个月。这项研究表明，金属锌不会引起经常导致再狭窄的反应。低细胞密度和新生内膜组织厚度，以及腐蚀植入物内的组织再生，表明腐蚀锌具有最佳的生物相容性。此外，超过6.5个月的新生内膜组织厚度没有进展或锌种植体附近有平滑肌细胞的存在，表明锌腐蚀的产物可能抑制炎性细胞和平滑肌细胞的活动。
Although corrosion resistant bare metal stents are considered generally effective, their permanent presence in a diseased artery is an increasingly recognized limitation due to the potential for long-term complications. We previously reported that metallic zinc exhibited an ideal biocorrosion rate within murine aortas, thus raising the possibility of zinc as a candidate base material for endovascular stenting applications. This study was undertaken to further assess the arterial biocompatibility of metallic zinc. Metallic zinc wires were punctured and advanced into the rat abdominal aorta lumen for up to 6.5 months. This study demonstrated that metallic zinc did not provoke responses that often contribute to restenosis. Low cell densities and neointimal tissue thickness, along with tissue regeneration within the corroding implant, point to optimal biocompatibility of corroding zinc. Furthermore, the lack of progression in neointimal tissue thickness over 6.5 months or the presence of smooth muscle cells near the zinc implant suggest that the products of zinc corrosion may suppress the activities of inflammatory and smooth muscle cells.