THE SYNOVIAL-LIKE MEMBRANE AT THE BONE-CEMENT INTERFACE IN LOOSE TOTAL HIP REPLACEMENTS AND ITS PROPOSED ROLE IN BONE LYSIS
THE SYNOVIAL-LIKE MEMBRANE AT THE BONE-CEMENT INTERFACE IN LOOSE TOTAL HIP REPLACEMENTS AND ITS PROPOSED ROLE IN BONE LYSIS
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DOI：
10.2106/00004623-198365050-00001
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发表时间：
1983-01-01
影响因子：
5.3
通讯作者：
HARRIS, WH
中科院分区：
文献类型：
--
作者：
GOLDRING, SR;SCHILLER, AL;HARRIS, WH
从20例松动、非感染性全髋关节置换术失败的患者中取出骨-骨水泥界面处存在的膜，其位置明显远离术后重新形成的假关节囊。仔细标记膜的方向，以识别与骨水泥接触的表面。通过细胞培养、器官培养和评估其合成前列腺素E2和胶原酶的能力，对膜进行组织学、组织化学研究。这种膜，而不是一个难以描述的所谓的纤维膜，具有滑膜样衬里的组织学和组织化学特征。滑膜样细胞与骨水泥层相邻。在它们深处巨噬细胞占主导地位。炎症细胞不存在。这种膜的细胞培养物含有类似于在正常和类风湿性滑膜组织的细胞培养物中发现的星状细胞。这种膜具有产生大量前列腺素E2和胶原酶的能力。
The membrane present at the bone-cement interface was retrieved from 20 patients with a loose, non-septic failed total hip replacement at a site clearly remote from the pseudocapule that reformed postoperatively. The orientation of the membrane was carefully marked to identify the surface in contact with cement. The membrane was studied histologically, histochemically, by cell culture, by organ culture and by assessment of its ability to synthesize prostaglandin E2 and collagenase. This membrane, rather than being a nondescript so-called fibrous membrane, has the histological and histochemical characteristics of a synovial-like lining. The synovial-like cells are adjacent to the cement layer. Deep to them macrophages predominate. Inflammatory cells are absent. Cell cultures of this membrane contain stellate cells similar to those found in cell cultures of normal and rheumatoid synovial tissue. This membrane has the capacity to produce large amounts of prostaglandin E2 and collagenase.