Regulation of tight junctions in upper airway epithelium.
Regulation of tight junctions in upper airway epithelium.
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DOI：
10.1155/2013/947072
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发表时间：
2013
影响因子：
--
通讯作者：
Sawada N
中科院分区：
文献类型：
--
作者：
Kojima T;Go M;Takano K;Kurose M;Ohkuni T;Koizumi J;Kamekura R;Ogasawara N;Masaki T;Fuchimoto J;Obata K;Hirakawa S;Nomura K;Keira T;Miyata R;Fujii N;Tsutsumi H;Himi T;Sawada N
包括鼻腔在内的上呼吸道的粘膜屏障是暴露于吸入抗原的第一个部位，在先天免疫方面在宿主防御中起重要作用，并且在很大程度上受上皮细胞的紧密连接调节。紧密连接分子在M细胞和树突状细胞以及上气道上皮细胞中表达。各种抗原通过鼻粘膜中的细胞被采样、运输和释放到淋巴细胞，同时它们保持屏障的完整性。正常人鼻上皮细胞（HNECs）中紧密连接分子的表达和屏障功能受到多种刺激的影响，包括生长因子、TLR配体和细胞因子。此外，上皮来源的胸腺基质淋巴细胞生成素（TSLP）是包括过敏性鼻炎在内的过敏性炎症性疾病的主开关，其增强了屏障功能以及HNEC中紧密连接分子的增加。此外，呼吸道合胞病毒感染体外HNECs诱导紧密连接分子的表达和屏障功能以及促炎细胞因子的释放。本文总结了最近的进展，我们的理解，在正常的，过敏性和RSV感染的条件下，上气道上皮细胞的紧密连接的调节。
The mucosal barrier of the upper respiratory tract including the nasal cavity, which is the first site of exposure to inhaled antigens, plays an important role in host defense in terms of innate immunity and is regulated in large part by tight junctions of epithelial cells. Tight junction molecules are expressed in both M cells and dendritic cells as well as epithelial cells of upper airway. Various antigens are sampled, transported, and released to lymphocytes through the cells in nasal mucosa while they maintain the integrity of the barrier. Expression of tight junction molecules and the barrier function in normal human nasal epithelial cells (HNECs) are affected by various stimuli including growth factor, TLR ligand, and cytokine. In addition, epithelial-derived thymic stromal lymphopoietin (TSLP), which is a master switch for allergic inflammatory diseases including allergic rhinitis, enhances the barrier function together with an increase of tight junction molecules in HNECs. Furthermore, respiratory syncytial virus infection in HNECs in vitro induces expression of tight junction molecules and the barrier function together with proinflammatory cytokine release. This paper summarizes the recent progress in our understanding of the regulation of tight junctions in the upper airway epithelium under normal, allergic, and RSV-infected conditions.
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DOI：
10.1083/jcb.200510043
发表时间：
2005-12-19
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ikenouchi J;Furuse M;Furuse K;Sasaki H;Tsukita S;Tsukita S
通讯作者：
Tsukita S
影响因子：
64.8
作者：
Alexopoulou, L;Holt, AC;Flavell, RA
通讯作者：
Flavell, RA
通过表达突变型紧密连接膜蛋白，细胞旁通透性和跨上皮电阻的功能性分离以及顶端-基底外侧膜内扩散屏障的破坏。
影响因子：
7.8
作者：
Balda, M S;Whitney, J A;Flores, C;Gonzalez, S;Cereijido, M;Matter, K
通讯作者：
Matter, K
影响因子：
2.8
作者：
Georgy, Mary S;Peters, Anju T
通讯作者：
Peters, Anju T
影响因子：
3.1
作者：
Giannasca, PJ;Boden, JA;Monath, TP
通讯作者：
Monath, TP