Aging, Atherosclerosis, and IGF-1
Aging, Atherosclerosis, and IGF-1
复制标题
DOI：
10.1093/gerona/gls102
复制
发表时间：
2012-06-01
影响因子：
5.1
通讯作者：
Delafontaine, Patrice
中科院分区：
文献类型：
--
作者：
Higashi, Yusuke;Sukhanov, Sergiy;Delafontaine, Patrice
胰岛素样生长因子1（IGF-1）是一种内分泌和自分泌/旁分泌生长因子，在血浆中以高水平循环，并在大多数细胞类型中表达。IGF-1对发育、细胞生长和分化以及组织修复有重要影响。最近的证据表明，IGF-1在动物模型中降低动脉粥样硬化负荷并改善动脉粥样硬化斑块稳定性的特征。这种动脉粥样硬化保护作用的潜在机制包括IGF-1诱导的氧化应激减少、细胞凋亡、促炎信号传导和内皮功能障碍。衰老与血管氧化应激和血管疾病的增加有关，这表明IGF-1可能对血管衰老过程产生有益的影响。在这篇综述中，我们将提供一个全面的更新IGF-1的能力，调节血管氧化应激和限制动脉粥样硬化和血管并发症的老化。
Insulin-like growth factor 1 (IGF-1) is an endocrine and autocrine/paracrine growth factor that circulates at high levels in the plasma and is expressed in most cell types. IGF-1 has major effects on development, cell growth and differentiation, and tissue repair. Recent evidence indicates that IGF-1 reduces atherosclerosis burden and improves features of atherosclerotic plaque stability in animal models. Potential mechanisms for this atheroprotective effect include IGF-1-induced reduction in oxidative stress, cell apoptosis, proinflammatory signaling, and endothelial dysfunction. Aging is associated with increased vascular oxidative stress and vascular disease, suggesting that IGF-1 may exert salutary effects on vascular aging processes. In this review, we will provide a comprehensive update on IGF-1's ability to modulate vascular oxidative stress and to limit atherogenesis and the vascular complications of aging.