Radiotherapy following breast-conserving surgery for screen-detected ductal carcinoma in situ:: indications and utilisation in the UK. Interim findings from the Sloane Project
Radiotherapy following breast-conserving surgery for screen-detected ductal carcinoma in situ:: indications and utilisation in the UK. Interim findings from the Sloane Project
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DOI：
10.1038/sj.bjc.6603945
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发表时间：
2007-09-11
影响因子：
8.8
通讯作者：
Bishop, H.
中科院分区：
文献类型：
--
作者：
Dodwell, D.;Clements, K.;Bishop, H.
导管原位癌(DCIS)保乳手术(BCS)后放射治疗(RT)的应用因国家、先例和偏见而异。对英国斯隆项目中现有数据的初步分析结果可以在DCIS的BCS后选择佐剂RT的不确定性的背景下得到赞赏。在联合王国内，RT的使用存在明显的地域差异。然而，总的来说，接受BCS治疗的DCIS患者，如果他们有大的(=15 mm)、中等或高度级别的肿瘤，或者如果存在中央粉刺样坏死，那么他们更有可能计划(并给予)RT。出乎意料的是，保证金宽度似乎并未对决策过程产生重大影响。然而，Van Nuys预后指数在单变量分析中确实显著影响了计划RT的机会，这表明临床医生可能已经开始在常规实践中使用这一评分系统来辅助决策。
Use of radiotherapy (RT) after breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS) varies according to country, precedent and prejudice. Results from a preliminary analysis of the data available within the UK Sloane Project can be appreciated in the context of the uncertainty concerning the selection of adjuvant RT following BCS for DCIS. There was a marked geographical variation in the use of RT within the United Kingdom. However, overall, patients with DCIS treated with BCS were significantly more likely to have RT planned (and given) if they had large (>= 15 mm), intermediate or high-grade tumours or if central comedo-type necrosis was present. Unexpectedly, margin width did not appear to have a significant effect on the decision-making process. However, the Van Nuys Prognostic Index did significantly affect the chances of getting planned RT in the univariate analysis, suggesting that clinicians may be starting to use this scoring system in routine practice to assist in decision making.