Clubbed thiazoles by MAOS: A novel approach to cyclin-dependent kinase 5/p25 inhibitors as a potential treatment for Alzheimer's disease
Clubbed thiazoles by MAOS: A novel approach to cyclin-dependent kinase 5/p25 inhibitors as a potential treatment for Alzheimer's disease
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DOI：
10.1016/j.bmc.2007.01.043
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发表时间：
2007-04-01
影响因子：
3.5
通讯作者：
Kaur, Ranjit
中科院分区：
文献类型：
--
作者：
Shiradkar, Mahendra Ramesh;Akula, Kalyan Chakravarthy;Kaur, Ranjit
A novel clubbed triazolyl thiazole series of cdk5/p25 inhibitors, potentially useful for the treatment of Alzheimer's disease, is disclosed. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain cdk5/p25 and thus have potential as possible treatments for Alzheimer's disease. (c) 2007 Elsevier Ltd. All rights reserved.
