THE USE OF LONG-DURATION CURRENT PULSES TO ASSESS NERVE SURVIVAL
THE USE OF LONG-DURATION CURRENT PULSES TO ASSESS NERVE SURVIVAL
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DOI：
10.1016/0378-5955(94)90039-6
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发表时间：
1994-07-01
期刊：
影响因子：
2.8
通讯作者：
ROBINSON, BK
中科院分区：
文献类型：
--
作者：
MILLER, CA;ABBAS, PJ;ROBINSON, BK
本研究探讨了长持续时间的电流脉冲在评估不同程度的逆行神经变性的耳朵的听神经的状态的有用性。在急性耳蜗植入和电诱发听性脑干反应（EABR）收集之前，用氨基糖苷类药物对豚鼠进行了麻醉。波I诱发的长时间电流脉冲的分析表明，这种诱发反应是敏感的听神经的外周过程的退化。与螺旋神经节细胞密度的相关性表明，EABR的措施，获得了长时间的脉冲与先前建立的估计神经存活。进一步的分析表明，这种测量可以提供关于神经退行性状态的独特信息。阈值EABR措施，使用长持续时间的脉冲明显比其他措施更具有地方特异性。此外，结果表明，长时间的脉冲可能是敏感的退化过程的两个阶段：周边过程的退化和随后的退化的神经过程中央的螺旋神经节。
This study investigated the usefulness of long-duration current pulses in assessing the status of the auditory nerve in ears with various degrees of retrograde neural degeneration. Guinea pigs were deafened with aminoglycosides prior to acute implantation of the cochlea and collection of electrically evoked auditory brainstem responses (EABRs). Analysis of wave I evoked with long-duration current pulses suggests that this evoked response is sensitive to degeneration of the peripheral processes of the auditory nerve. Correlations with spiral ganglion cell density show that EABR measures obtained with long-duration pulses are comparable to those previously established for estimating nerve survival. Further analysis indicates that this measure may provide unique information about the degenerative state of the nerve. Threshold EABR measures using long-duration pulses are evidently more place-specific than other measures. Also, results suggest that long-duration pulses may be sensitive to two phases of the degenerative process: degradation of the peripheral processes and subsequent degeneration of neural processes central to the spiral ganglion.