Preparation of biodegradable PLA/PLGA membranes with PGA mesh and their application for periodontal guided tissue regeneration
Preparation of biodegradable PLA/PLGA membranes with PGA mesh and their application for periodontal guided tissue regeneration
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DOI：
10.1088/1748-6041/4/5/055001
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发表时间：
2009-10-01
影响因子：
4
通讯作者：
Kang, Inn-Kyu
中科院分区：
文献类型：
--
作者：
Kim, Eun Jin;Yoon, Suk Joon;Kang, Inn-Kyu
制备了一种可生物降解的聚乳酸（PLA）/聚（乙交酯-丙交酯）共聚物（PLGA）膜和聚乙醇酸（PGA）网片，以帮助牙周缺损组织的有效再生。本研究中使用的微孔膜由可生物降解的聚合物组成，并且似乎具有为牙周组织再生提供适当性质的结构。基于白蛋白渗透试验，已知生物可降解膜表现出适当的营养素渗透性。膜保持其物理完整性6-8周，这可能足以在牙周袋中保留空间。针对膜的生物相容性评价进行了细胞附着和细胞毒性试验。因此，膜未显示任何细胞毒性。动物试验证实了生物可降解膜的安全性和治疗效果。
A biodegradable polylactic acid (PLA)/poly(glycolide-co-lactide) copolymer (PLGA) membrane with polyglycolic acid (PGA) mesh was prepared to aid the effective regeneration of defective periodontal tissues. The microporous membrane used in this study consists of biodegradable polymers, and seems to have a structure to provide appropriate properties for periodontal tissue regeneration. Based on the albumin permeation test, it is known that the biodegradable membrane exhibits the suitable permeability of nutrients. The membrane maintained its physical integrity for 6-8 weeks, which could be sufficient to retain space in the periodontal pocket. Cell attachment and cytotoxicity tests were performed with respect to the evaluation of biocompatibility of the membrane. As a result, the membrane did not show any cytotoxicity. The safety and therapeutic efficacies of the biodegradable membranes were confirmed in animal tests.