Knee osteoarthritis associated with different kinds of amyloid deposits and the impact of aging on type of amyloid
Knee osteoarthritis associated with different kinds of amyloid deposits and the impact of aging on type of amyloid
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DOI：
10.3109/13506129.2015.1115758
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发表时间：
2016-01
期刊：
影响因子：
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通讯作者：
Akihiro Yanagisawa;M. Ueda;Takanao Sueyoshi;E. Nakamura;M. Tasaki;G. Suenaga;Hiroaki Motokawa;Risa Toyoshima;Y. Kinoshita;Y. Misumi;T. Yamashita;M. Sakaguchi;P. Westermark;H. Mizuta;Y. Ando
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文献类型：
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作者：
Akihiro Yanagisawa;M. Ueda;Takanao Sueyoshi;E. Nakamura;M. Tasaki;G. Suenaga;Hiroaki Motokawa;Risa Toyoshima;Y. Kinoshita;Y. Misumi;T. Yamashita;M. Sakaguchi;P. Westermark;H. Mizuta;Y. Ando
摘要淀粉样变性是一种蛋白质构象紊乱，淀粉样纤维聚集在细胞外，导致器官功能障碍。最近，两种不同的淀粉样蛋白，甲状腺素运载蛋白（TTR）和载脂蛋白A-I（Apo A-I），被确定在膝关节骨性关节炎（OA）患者的膝关节淀粉样蛋白沉积。然而，与膝关节中这两种淀粉样蛋白沉积相关的临床病理学差异仍有待澄清。在这里，我们研究了与膝关节OA相关的膝关节淀粉样蛋白沉积的临床病理学特征和淀粉样蛋白沉积的生化特征。我们发现，我们所有的膝关节OA患者的膝关节，特别是半月板中有淀粉样蛋白沉积，这些沉积物主要来自TTR和/或Apo A-I。然而，一些膝关节OA患者有未分类的淀粉样蛋白沉积。我们的一个有趣的观察是关于衰老对每种淀粉样蛋白形成的不同影响。ATTR沉积物的形成频率随年龄的增长而明显增加，而AApo A-I沉积物的形成频率则随年龄的增长而下降。此外，我们发现，约16%的膝关节OA患者在半月板中出现ATTR/AApo A-I双沉积。因此，淀粉样蛋白沉积可能是与膝关节OA相关的常见组织病理学特征。此外，老化可能诱导膝关节OA老年患者膝关节ATTR形成，而AApo A-I形成可能与年龄呈负相关。
Abstract Amyloidosis is a protein conformational disorder in which amyloid fibrils accumulate in the extracellular space and induce organ dysfunction. Recently, two different amyloidogenic proteins, transthyretin (TTR) and apolipoprotein A-I (Apo A-I), were identified in amyloid deposits in knee joints in patients with knee osteoarthritis (OA). However, clinicopathological differences related to those two kinds of amyloid deposits in the knee joint remain to be clarified. Here, we investigated the clinicopathological features related to these knee amyloid deposits associated with knee OA and the biochemical characteristics of the amyloid deposits. We found that all of our patients with knee OA had amyloid deposits in the knee joints, especially in the meniscus, and those deposits were primarily derived from TTR and/or Apo A-I. Some patients with knee OA, however, had unclassified amyloid deposits. One of our interesting observations concerned the different effects of aging on each type of amyloid formed. The frequency of formation of ATTR deposits clearly increased with age, but that of AApo A-I deposits decreased. Furthermore, we found that ∼16% of patients with knee OA developed ATTR/AApo A-I double deposits in the meniscus. Amyloid deposition may therefore be a common histopathological feature associated with knee OA. Also, aging may induce ATTR formation in the knee joint in elderly patients with knee OA, whereas AApo A-I formation may be inversely correlated with age.