Arterial stiffness, physical activity, and atrial natriuretic peptide gene polymorphism in older subjects
Arterial stiffness, physical activity, and atrial natriuretic peptide gene polymorphism in older subjects
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DOI：
10.1291/hypres.31.767
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发表时间：
2008-04-01
影响因子：
5.4
通讯作者：
Matsuda, Mitsuo
中科院分区：
文献类型：
--
作者：
Iemitsu, Motoyuki;Maeda, Seiji;Matsuda, Mitsuo
随着年龄的增长，动脉僵硬的增加与几种病理状态有关，包括高血压和动脉硬化。经常锻炼可以改善衰老导致的动脉僵硬增加，并对这些疾病具有保护作用。然而，并不是所有的人对锻炼的反应程度都是一样的。心钠素(ANP)参与基础血压、血流量和血管张力的调节。本研究旨在阐明心钠素相关基因的基因多态是否影响运动诱导的动脉僵硬的改善。我们对291名健康的日本中老年受试者(63+/-1岁)进行了一项横断面研究，考察了每日体力活动引起的动脉僵硬改善(通过臂踝动脉脉搏波速度(BaPWV)估计)与ANP清除受体(NPR-C)外显子8的valine32蛋氨酸(V32M：664G和GT；A)和天冬氨酸521天冬氨酸(N521 D：1780A和GT；G)基因多态之间的关系。活动组基础baPWV显著降低，但血压无明显变化。与非活动期相比，携带ANP-VV基因的活动期患者的baPWV显著降低，血浆ANP水平显著升高，但与Vm+MM基因携带者无明显差异。此外，在ANP-VV基因携带者中，baPWV与血浆ANP水平呈负相关，而在VM+MM个体中则不相关。我们的结果表明，日本老年受试者的ANP基因多态性可能会影响常规运动对心血管的反应。
An increase in arterial stiffness with advancing age is associated with several pathological states, including hypertension and arteriosclerosis. Regular exercise improves the aging-induced increase in arterial stiffness and has a protective effect against these diseases. However, not all individuals respond to exercise to the same extent. Atrial natriuretic peptide (ANP) is involved in the regulation of basal blood pressure, blood flow, and vascular tone. The present study was designed to clarify whether gene polymorphisms in ANP-related genes affect exercise-induced improvements in arterial stiffness. We performed a cross-sectional study of 291 healthy middle-aged and older Japanese subjects (63 +/- 1 years), examining the relationship between daily physical activity-induced improvements in arterial stiffness, estimated by brachial-ankle arterial pulse wave velocity (baPWV), and the gene polymorphisms of valine32methionine (V32M: 664G>A) in exon 1 of ANP and asparagine521 aspartic acid (N521 D: 1780A>G) in exon 8 of the ANP clearance receptor (NPR-C). The baseline baPWV was significantly lower in the active group, but no differences were seen in blood pressure. Active subjects with the ANP-VV genotype had significantly lower baPWV and higher plasma ANP levels compared with inactive subjects, but there were no variations related to the VM+MM genotype. Additionally, baPWV and plasma ANP levels were negatively correlated in ANP-VV genotype subjects, but were not correlated in VM+MM individuals. Our results suggest that ANP polymorphism in older Japanese subjects may affect the cardiovascular response to regular exercise.