Involvement of nitric oxide in the elimination of a transient retinotectal projection in development.
Involvement of nitric oxide in the elimination of a transient retinotectal projection in development.
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DOI：
10.1126/science.7521541
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发表时间：
1994-09
期刊：
影响因子：
56.9
通讯作者：
H. H. Wu-H.;C. Williams;S. McLoon
中科院分区：
文献类型：
--
作者：
H. H. Wu-H.;C. Williams;S. McLoon
从眼睛到大脑的轴突连接的成人模式是在发育过程中通过一组粗略有序的连接的细化而产生的。在雏鸡视觉系统中，精细化通常会导致同侧视网膜顶盖连接的丧失。一氧化氮合成的抑制减少了这些瞬态连接的损失。由于一氧化氮由与视网膜轴突连接的顶盖细胞表达，并且由于顶盖细胞合成一氧化氮的减少导致视网膜轴突连接的变化，因此一氧化氮可能在发育过程中充当从顶盖细胞返回到视网膜轴突的信使。
The adult pattern of axonal connections from the eye to the brain arises during development through the refinement of a roughly ordered set of connections. In the chick visual system, refinement normally results in the loss of the ipsilateral retinotectal connections. Inhibition of nitric oxide synthesis reduced the loss of these transient connections. Because nitric oxide is expressed by tectal cells with which retinal axons connect and because reduction of nitric oxide synthesis by tectal cells resulted in a change in the connections of retinal axons, nitric oxide probably serves as a messenger from tectal cells back to retinal axons during development.