Toxicity evaluation of cadmium-containing quantum dots: A review of optimizing physicochemical properties to diminish toxicity
Toxicity evaluation of cadmium-containing quantum dots: A review of optimizing physicochemical properties to diminish toxicity
复制标题
含镉量子点的毒性评估：优化理化性质以降低毒性的综述
DOI：
10.1016/j.colsurfb.2021.111609
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发表时间：
2021-02-13
影响因子：
5.8
通讯作者：
He, Zhiguo
中科院分区：
文献类型：
--
作者：
Hu, Liang;Zhong, Hui;He, Zhiguo
荧光量子点因其优异的光学性质以及在生物和生物医学领域的广泛应用而受到广泛关注。尽管如此，由于镉离子的自由释放和纳米尺寸效应，含镉量子点的细胞毒性评估一直受到人们的强烈关注。本文综述了具有代表性的含镉量子点的合成方法及其应用。然后讨论了量子点从细胞研究到动物模型的毒性评价，有助于加深我们对量子点细胞毒性的认识，并提出了其毒性机制。讨论了量子点的几个关键物理化学性质，并从细胞毒性最小的角度提出了优化量子点设计的建议。最后，量子点毒性评估的精确检测技术和系统方法有望在未来实现进一步的突破，特别是原位、实时、快速的定量分析方法。
Fluorescent quantum dots (QDs) have received extensive attention because of their excellent optical properties and wide utilization in biological and biomedical areas. Nonetheless, there have been intense concerns on the cytotoxicity assessment of cadmium-containing QDs due to free cadmium ions release and nano-size effects. This paper reviews the representative synthetic strategies for preparation of cadmium-containing QDs and their applications. Then the toxicity assessments of QDs from cell studies to animal models are discussed, which can aid in improving our understanding of the cytotoxicity of QDs, and the toxicity mechanism is proposed. Several critical physicochemical properties of QDs are discussed and suggestions are provided for optimizing QDs design in view of minimal cytotoxicity. Finally, accurate detection techniques and systematic methodologies for the toxicity assessment of QDs are expected to achieve further breakthroughs in the future, especially in-situ, realtime, and rapid quantitative analysis methods.