Enantioselective organocatalyzed Henry reaction with fluoromethyl ketones
Enantioselective organocatalyzed Henry reaction with fluoromethyl ketones
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DOI：
10.1039/b807640e
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发表时间：
2008-01-01
影响因子：
4.9
通讯作者：
Umani-Ronchi, Achille
中科院分区：
文献类型：
--
作者：
Bandini, Marco;Sinisi, Riccardo;Umani-Ronchi, Achille
本文提出了一种新型C9-苯甲酰基铜杂环化合物，用于硝醛与氟甲基酮的缩合反应，具有显著的普遍性。三氟甲基酮和二氟甲基酮在温和的反应条件和较低的催化剂负载量(1-5mol%)下都具有良好的立体诱导水平(ee 76-99%)。
Remarkable generality in scope of new C9-benzoylcupreines bearing electron-withdrawing substituents for the nitroaldol condensation with fluoromethyl ketones is presented. Both tri- and difluoromethyl ketones provided excellent levels of stereo-induction (ee 76-99%) under mild reaction conditions and low loading of catalyst (1-5 mol%).