An analysis of two-period crossover designs with carry-over effects.
An analysis of two-period crossover designs with carry-over effects.
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DOI：
10.1002/sim.4780111415
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发表时间：
1992
影响因子：
2
通讯作者：
N. Laird;Jonathan S. Skinner;M. Kenward
中科院分区：
文献类型：
--
作者：
N. Laird;Jonathan S. Skinner;M. Kenward
The crossover design is a type of longitudinal study with subjects receiving different treatments in different time periods. When carry-over effects are absent, the usual crossover design is structured so that all the information about treatment effects is contained in the within-subject contrasts; standard analyses are based on these within-subject contrasts and ignore any between-subject information. With carry-over effects present these standard analyses can be very inefficient, especially for suboptimal designs. We describe alternative approaches based on methods for the analysis of longitudinal data.
