Frequency of maternal licking and grooming correlates negatively with vulnerability to cocaine and alcohol use in rats
Frequency of maternal licking and grooming correlates negatively with vulnerability to cocaine and alcohol use in rats
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DOI：
10.1016/j.pbb.2008.04.012
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发表时间：
2008-09-01
影响因子：
3.6
通讯作者：
Kuhar, M. J.
中科院分区：
文献类型：
--
作者：
Francis, D. D.;Kuhar, M. J.
由于幼鼠的舔舐和梳理行为会影响成年幼鼠的某些行为，我们测试了母鼠分离协议中的舔舐和梳理得分是否与成年幼鼠的可卡因或乙醇自我服用相关。该方案产生了与水坝分离0 (MSO), 15 （MS15）或180 （MS180）分钟的凋落物，以及未处理（NH）组。早期研究显示，两种药物的自我给药在MS15组中最低，在NH组中最高，在其他组中居中。舔和梳理得分与药物摄入呈负相关，这表明母性对幼犬的照顾会影响成年幼犬的药物使用。(C) 2008爱思唯尔公司版权所有。
Because licking and grooming behavior of dams with pups can influence some behaviors of pups when they are adults, we tested if licking and grooming scores in a maternal separation protocol correlated with cocaine or ethanol self-administration in the pups as adults. The protocol produced litters that were separated from dams for 0 (MSO), 15 (MS15) or 180 (MS180) min, and a nonhandled (NH) group as well. Self-administration of both drugs as shown in earlier studies was lowest in the MS15 group, highest in the NH group and intermediate in the other groups. Licking and grooming scores correlated negatively with drug intake and suggests that maternal care of pups can influence drug use in pups when they are adults. (C) 2008 Elsevier Inc. All rights reserved.