Automated quantification of the spatial extent of perfusion defects and viability on myocardial contrast echocardiography
Automated quantification of the spatial extent of perfusion defects and viability on myocardial contrast echocardiography
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DOI：
10.1016/j.echo.2005.10.024
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发表时间：
2006-04-01
影响因子：
6.5
通讯作者：
Lindner, JR
中科院分区：
文献类型：
--
作者：
Micari, A;Sklenar, J;Lindner, JR
低灌注或活力的空间范围在冠状动脉疾病患者的治疗中是重要的。我们假设计算机像素强度阈值分析（PITA）可用于心肌超声造影（NICE）期间灌注缺陷大小的自动分析。为了进行校准研究，对6只缺血再灌注犬进行了NICE。梗死面积由PITA确定，它自动计算心肌内未超过最大对比度增强预定阈值的像素百分比。阈值为最大梗死面积的10%，与组织学染色测定的梗死面积密切相关。为了临床验证，我们对30例急性心肌梗死患者进行了首次经皮冠状动脉介入治疗（PCI）前的NICE检查，以测量危险区域；在PCI术后5天和4周内确定梗死面积。阈值为10%的PITA与专家阅读器平面测量法在减去背景的彩色编码图像集上测量的缺陷尺寸密切相关(r = 0.95， P
The spatial extent of hypoperfusion or viability is important in the treatment of patients with coronary artery disease. We hypothesized that computerized pixel intensity threshold analysis (PITA) could be used for the automated analysis of perfusion defect size during myocardial contrast echocardiography (NICE). For calibration studies, NICE was performed in 6 dogs undergoing ischemia and reperfusion. Infarct size was determined by PITA, which automatically calculates the percentage of pixels within the myocardium that fail to exceed a predetermined threshold of maximum contrast enhancement. A threshold of 10% of maximum yielded infarct sizes that most closely correlated with those determined by histologic staining. For clinical validation, NICE was performed in 30 patients with acute myocardial infarction before primary percutaneous coronary intervention (PCI) for measurement of risk area; and within 5 days and at 4 weeks after PCI to determine infarct size. The defect size by PITA with a 10% threshold value closely correlated with those measured by expert reader planimetry on background-subtracted color-coded image sets (r = 0.95, P