Facile polymerization in a bicellar template to produce polymer nano-rings
Facile polymerization in a bicellar template to produce polymer nano-rings
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DOI：
10.1016/j.jcis.2022.09.141
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发表时间：
2022-10-20
影响因子：
9.9
通讯作者：
Nieh，Mu-Ping
中科院分区：
文献类型：
--
作者：
Liu，Chung-Hao;Cheu，Catherine;Nieh，Mu-Ping
一个明确定义的盘状双胞由三个脂质组成，特别是两性离子长链1，2-二棕榈酰磷酸胆碱（DPPC）和短链1，2-二己酰磷酸胆碱（DHPC）掺杂阴离子1，2-二棕榈酰磷酸甘油（DPPG），为合成疏水聚合物纳米环提供了一个通用的模板。DPPC/DHPC/DPPG的脂质摩尔比为0.71/0.25/0.04。详细的调查和讨论是基于苯乙烯，但测试其他三个乙烯基单体。ExperimentsThe结构的纳米环是通过详细的分析，小角X射线/中子散射（SAXS和SANS）数据和透射电子显微镜（TEM），由差示扫描量热法（DSC）的聚合前后的数据支持。研究了苯乙烯与脂质的比例在1：50 ~ 1：10之间的样品。结果发现苯乙烯单体最初位于盘状平面区（富含长链脂质）和盘状边缘区（富含短链脂质）。在聚合过程中，它们迁移到流动性更强的边缘区域。其形成机制涉及疏水相互作用、有序相和无序相之间聚苯乙烯的不匹配的可溶解性以及长脂酰基链的结晶性的相互作用。这种简便的合成方法被证明适用于几种疏水单体。定义明确的纳米环大大提高了界面面积，并有可能成为功能材料的构建块，如果单体与所需的功能，为未来的应用。
HypothesisA well-defined discoidal bicelle composed of three lipids, specifically zwitterionic long-chain 1,2‑dipalmitoyl phosphocholine (DPPC) and short-chain 1,2‑dihexanoyl phosphocholine (DHPC) doped with anionic 1,2‑dipalmitoyl phosphoglycerol (DPPG) provides a generalized template for the synthesis of hydrophobic polymer nano-rings. The lipid molar ratio of DPPC/DHPC/DPPG is 0.71/0.25/0.04. The detailed investigation and discussion were based on styrene but tested on three other vinyl monomers.ExperimentsThe structure of nano-rings is identified through the detailed analysis of small angle X-ray/neutron scattering (SAXS and SANS) data and transmission electron micrographs (TEM), supported by the differential scanning calorimetric (DSC) data before and after polymerization. The investigation covers samples with a styrene-to-lipid ratio ranged varied from 1:50 to 1:10.FindingsThe styrene monomers are initially located at both the discoidal planar (long-chain lipid rich) and rim (short-chain lipid rich) regions. During polymerization, they migrate to the more fluid rim regionsection. The formation mechanism involves the interplay of hydrophobic interaction, mismatched miscibility of polystyrene between the ordered and disordered phases, and crystallinity of the long lipid acyl chains. This facile synthesis is proven applicable for several hydrophobic monomers. The well-defined nano-rings greatly enhance the interfacial area and have the potential to be the building blocks for functional materials, if monomers are incorporated with desirable functions, for future applications.