The level of cardiovascular risk factors in bipolar disorder equals that of schizophrenia: A comparative study
The level of cardiovascular risk factors in bipolar disorder equals that of schizophrenia: A comparative study
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DOI：
10.4088/jcp.v68n0614
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发表时间：
2007-06-01
影响因子：
5.3
通讯作者：
Andreassen, Ole A.
中科院分区：
文献类型：
--
作者：
Birkenaes, Astrid B.;Opjordsmoen, Stein;Andreassen, Ole A.
目的：在精神分裂症患者中，躯体死亡率的增加与包括吸烟和代谢综合征在内的心血管危险因素的高患病率相对应。在双相情感障碍中，心血管风险在很大程度上仍是未知的。这项研究比较了双相情感障碍和精神分裂症患者在自然条件下吸烟和代谢障碍的患病率。方法：2002年10月至2005年12月临床分组的纵向数据来自奥斯陆TOP研究(DSM-IV双相情感障碍[N=110]和精神分裂症[N=163])。参考数据来自2000年至2001年奥斯陆健康研究(同一地区的18,770人)。对不同诊断组间的背景变量、吸烟率和年龄调整后的代谢危险因素水平进行比较。结果：与精神分裂症患者相比，双相情感障碍患者具有更高的教育水平、更好的社会功能、更少的精神症状和更少的药物使用。在吸烟、肥胖、代谢综合征或糖尿病的患病率方面，诊断组之间没有显著差异。精神分裂症患者高密度脂蛋白胆固醇平均水平较低(p<；.001)，双相情感障碍患者平均收缩压较高(p<；0.05)。结论：与普通人群相比，双相情感障碍和精神分裂症患者心血管危险因素的患病率高得惊人，而两个诊断组的心血管危险因素患病率大致相同。
Objective: In schizophrenia, increased rates of somatic mortality have been shown to correspond with a high prevalence of cardiovascular risk factors, including smoking and the metabolic syndrome. In bipolar disorder, the amount of cardiovascular risk is still largely unknown. This study compares the prevalence of smoking and metabolic disturbances in bipolar disorder and schizophrenia in a representative sample of patients under naturalistic conditions. It also compares the prevalence of risk factors in each diagnostic group with the general population.Method: Longitudinal data on clinical groups from October 2002 through December 2005 were from the Oslo TOP Study (DSM-IV bipolar disorder [N = 110] and schizophrenia [N = 163]). Reference data were from the 2000 to 2001 Oslo Health Study (18,770 individuals of the same area). Background variables, prevalence of smoking, and age-adjusted levels of metabolic risk factors were compared between diagnostic groups. Risk factors in both groups were then compared with the general population.Results: Patients with bipolar disorder had higher levels of education, better social functioning, fewer psychiatric symptoms, and less use of medication than patients with schizophrenia. There was no significant difference between diagnostic groups in the prevalence of smoking, obesity, metabolic syndrome, or diabetes. The mean level of high density lipoprotein cholesterol was lower in schizophrenia (p < .001), and systolic blood pressure was higher in bipolar disorder (p < .05). Both diagnostic groups had a prevalence of cardiovascular risk factors about twice that of the general population.Conclusion: The prevalence of cardiovascular risk factors was alarmingly high for bipolar disorder and schizophrenia patients compared with the general population, and the prevalence was approximately the same in both diagnostic groups.