Antimicrobial cellulose hydrogels preparation with RIF loading from bamboo parenchyma cells: A green approach towards wound healing.
Antimicrobial cellulose hydrogels preparation with RIF loading from bamboo parenchyma cells: A green approach towards wound healing.
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DOI：
10.1016/j.ijbiomac.2022.01.046
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发表时间：
2022-01
影响因子：
8.2
通讯作者：
Shumei Zhang;Shaoyun Shan;Hengwei Zhang;Xin Gao;Xiaoning Tang;Keli Chen
中科院分区：
文献类型：
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作者：
Shumei Zhang;Shaoyun Shan;Hengwei Zhang;Xin Gao;Xiaoning Tang;Keli Chen
由于愈合过程中的细菌感染和频繁更换，伤口愈合是一个充满挑战和复杂的过程。具有可见性和生物相容性的水凝胶在伤口愈合过程中提供了方便有效的治疗。竹薄壁细胞因其高比表面积和化学试剂的可及性而在纤维素材料制造中具有巨大的潜力。在此，我们提出了一种通过在 DMAc/LiCl 系统中溶解，用竹实质纤维素简单方便地制造透明伤口敷料的方法。通过浸泡法将利福平（RIF）负载到水凝胶上。结果表明，纤维素水凝胶的最大载药率为82.13%。水凝胶负载的 RIF (HLR) 显示对革兰氏阴性菌和革兰氏阳性菌的抑菌圈分别为 19.11 mm 和 36.93 mm。在小鼠伤口模型中观察到，第11天伤口愈合超过60%。同时，RIF为水凝胶提供了卓越的抗菌性能，并促进伤口表皮细胞的增殖。观察结果表明，HLR 具有优异的透明度、抗菌效果、伤口愈合和生物相容性，在视觉伤口敷料材料中具有潜在的应用前景。
Wound healing is a challenged and complicated process due to the bacterial infections and frequent replacement in healing process. Hydrogels with properties of visibility and biocompatibility provided convenient and effective treatment during the wound healing process. Bamboo parenchyma cells have a great potential utilized on cellulosic materials fabrication for their high specific surface area and accessibility of chemical reagents. Herein, we present a simple and facile manufacture of transparent wound dressing from bamboo parenchymal cellulose via dissolution in DMAc/LiCl system. Rifampicin (RIF) was loaded on the hydrogel through immersion method. The result exhibited that the maximum drug loading efficiency of cellulose hydrogels was 82.13%. Hydrogel loaded RIF (HLR) showed that the inhibition zones against Gram-negative and Gram-positive bacteria were 19.11 mm and 36.93 mm, respectively. It was observed that the wound was healed more than 60% at 11th day in murine wound models. Meanwhile, RIF provided an exceptionally antibacterial property to hydrogels and promoted proliferation of epidermis cells in wound. As a result of observations, HLR demonstrating potential application in visual wound dressing materials for their excellent transparency, antibacterial effect, wound healing, and biocompatibility.