Body mass index trajectories and age at menopause in a British birth cohort
Body mass index trajectories and age at menopause in a British birth cohort
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DOI：
10.1016/j.maturitas.2008.02.009
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发表时间：
2008-04-20
期刊：
影响因子：
4.9
通讯作者：
Kuh, Diana
中科院分区：
文献类型：
--
作者：
Hardy, Rebecca;Mishra, Gita D.;Kuh, Diana
目的：本研究调查了15岁、20岁、26岁、36岁和43岁时的体重指数（BMI）以及20至36岁的BMI轨迹对绝经时间和激素治疗（HT）使用时间的影响，直至57岁。方法：一项具有全国代表性的英国队列研究，包括1583名出生于1946年3月的女性，前瞻性数据涵盖整个生命过程。到57岁时，共有695名妇女经历了自然绝经，而431名妇女在绝经前开始HT。考克斯回归模型表明，任何年龄的BMI或BMI轨迹与自然绝经时间之间没有显著相关性。在每个年龄段，BMI都很强（p <0.05）。
Objective: This study investigates the influence of body mass index (BMI) at ages 15, 20 26, 36, and 43, and of BMI trajectories from 20 to 36 years on the timing of menopause and hormone therapy (HT) use until age 57 years.Methods: A nationally representative British cohort of 1583 women born in March 1946 with prospective data across the life course.Results: By age 57, a total of 695 women had experienced natural menopause while 431 women had started HT prior to menopause. Cox regression models indicated no significant associations between BMI at any age, or BMI trajectory, and timing of natural menopause. At every age BMI was strongly (p