RXRγ and PPARγ ligands in combination to inhibit proliferation and invasiveness in colon cancer cells
RXRγ and PPARγ ligands in combination to inhibit proliferation and invasiveness in colon cancer cells
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DOI：
10.1016/j.canlet.2010.04.026
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发表时间：
2010-11-01
期刊：
影响因子：
9.7
通讯作者：
Orlandi, Marina
中科院分区：
文献类型：
--
作者：
Papi, Alessio;Rocchi, Paola;Orlandi, Marina
Nuclear retinoid X receptors (RXRs) and peroxisome proliferator-activated receptors (PPARs are potential candidates as drug target for cancer prevention and treatment. We investigated if the rexinoid 6-OH-11-O-hydroxyphenantrene (IIF) potentiates the antitumoral properties of PPAR gamma ligands as ciglitazone and pioglitazone, on two colon cancer cell lines: HCA-7 and HCT-116. Drugs inhibited cell growth and induced apoptosis synergistically. The combination resulted in a decrease of cyclooxigenase-2, metalloproteinases-2 and -9 expression level and activity while PPAR gamma, RXR gamma and tissue inhibitors of metalloproteinase-1 and -2 expression were increased. Finally, IIF potentiated PPAR transcriptional activity by enhancement of peroxisome proliferator response elements transactivation. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
