Bioinspired Shielding Strategies for Nanoparticle Drug Delivery Applications.
Bioinspired Shielding Strategies for Nanoparticle Drug Delivery Applications.
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DOI：
10.1021/acs.molpharmaceut.8b00292
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发表时间：
2018-08-06
影响因子：
4.9
通讯作者：
Steinmetz NF
中科院分区：
文献类型：
--
作者：
Gulati NM;Stewart PL;Steinmetz NF
Nanoparticle delivery systems offer advantages over free drugs, in that they increase solubility and biocompatibility. Nanoparticles can deliver a high payload of therapeutic molecules while limiting off target side effects. Therefore, delivery of an existing drug with a nanoparticle frequently results in an increased therapeutic index. Whether of synthetic or biologic origin, nanoparticle surface coatings are often required to reduce immune clearance and thereby increase circulation times allowing the carriers to reach their target site. To this end, polyethylene glycol (PEG) has long been used, with several PEGylated products reaching clinical use. Unfortunately, the growing use of PEG in consumer products has led to an increasing prevalence of PEG-specific antibodies in the human population, which in turn has fueled the search for alternative coating strategies. This review highlights alternative bio-inspired nanoparticle shielding strategies, which may be more beneficial moving forward than PEG and other synthetic polymer coatings.
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DOI：
10.1039/c7tb03106h
发表时间：
2018-04-21
期刊：
Journal of materials chemistry. B
影响因子：
--
作者：
Gulati NM;Pitek AS;Czapar AE;Stewart PL;Steinmetz NF
通讯作者：
Steinmetz NF
影响因子：
6
作者：
Bludau H;Czapar AE;Pitek AS;Shukla S;Jordan R;Steinmetz NF
通讯作者：
Steinmetz NF
由含有两性离子磺基甜菜碱的星形共聚物生成的新型 pH 敏感胶束，可实现有效的细胞内化
影响因子：
2.9
作者：
Cao, Jun;Zhai, Shuying;Gu, Zhongwei
通讯作者：
Gu, Zhongwei
影响因子：
3.7
作者：
Ebbesen, Morten F.;Olesen, Morten T. J.;Howard, Kenneth A.
通讯作者：
Howard, Kenneth A.
影响因子：
5.8
作者：
Gregoriadis, G;Jain, S;Laing, P
通讯作者：
Laing, P