Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum
Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum
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DOI：
10.1016/j.neurobiolaging.2003.12.001
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发表时间：
2004-03-01
影响因子：
4.2
通讯作者：
Gallagher, M
中科院分区：
文献类型：
--
作者：
Geinisman, Y;Ganeshina, O;Gallagher, M
本研究的目的是确定老年大鼠的空间学习障碍是否与海马突触的丧失有关。采用Morris水迷宫任务评估青年和老年大鼠的空间学习能力，并将老年动物分为学习受损组和学习未受损组。无偏体视学技术估计的CA1层辐射的整个体积中的轴棘突触的数量。结果表明，所有轴棘突触和穿孔和非穿孔亚型的总数保持不变，在CA1层辐射的老年学习障碍大鼠相比，老年学习未受损大鼠和年轻的成年人。因此，无论是年龄相关的空间学习缺陷，也没有先进的实足年龄与大鼠CA1层辐射轴棘突触的损失。(C)2003年爱思唯尔公司All rights reserved.
The aim of this study was to determine whether spatial learning deficits in aged rats are associated with a loss of hippocampal synapses. The Morris water maze task was used to assess the spatial learning capacity of young and aged rats and to attribute aged animals to learning-impaired and leaming-unimpaired groups. The number of axospinous synapses in the entire volume of the CA1 stratum radiatum was estimated with unbiased stereological techniques. The results show that the total number of all axospinous synapses and of their perforated and nonperforated subtypes remains constant in the CA1 stratum radiatum of aged learning-impaired rats as compared to aged leaming-unimpaired rats and to young adults. Thus, neither age-related deficits in spatial learning nor advanced chronological age are associated with a loss of axospinous synapses from the rat CA1 stratum radiatum. (C) 2003 Elsevier Inc. All rights reserved.