Epidermal growth factor induces cytogenetic damage in mammalian cells.
Epidermal growth factor induces cytogenetic damage in mammalian cells.
复制标题
表皮生长因子诱导哺乳动物细胞发生细胞遗传学损伤。
DOI：
10.1093/carcin/8.4.625
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发表时间：
1987
期刊：
影响因子：
4.7
通讯作者：
Little,JB
中科院分区：
文献类型：
--
作者：
Kelsey,KT;Nagasawa,H;Umans,RS;Little,JB
先前已经表明，有效的肿瘤促进剂，如佛波醇酯12-O-十四烷酰基佛波醇-13-乙酸酯（TPA），可以诱导哺乳动物细胞中的染色体畸变和姐妹染色单体交换（SCE）。表皮生长因子（EGF）也能诱导SCE。EGF和TPA并没有以相加的方式增加SCE的频率，这表明这些药物并不是通过完全独立的机制起作用的。
It has been previously shown that potent tumor promoters, such as the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), can induce both chromosomal aberrations and sister chromatid exchanges (SCE) in mammalian cells. We show here that epidermal growth factor (EGF) is also capable of inducing SCE. EGF and TPA did not enhance the frequency of SCE in an additive fashion, suggesting these agents do not act by completely independent mechanisms.