The Association Between Traumatic Brain Injury and Accelerated Fracture Healing: A Study on the Effects of Growth Factors and Cytokines
The Association Between Traumatic Brain Injury and Accelerated Fracture Healing: A Study on the Effects of Growth Factors and Cytokines
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DOI：
10.1007/s12031-020-01640-6
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发表时间：
2020-07-07
影响因子：
3.1
通讯作者：
Khorramdelazad, Hossein
中科院分区：
文献类型：
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作者：
Mollahosseini, Majid;Ahmadirad, Hadis;Khorramdelazad, Hossein
有证据表明，创伤性脑损伤（TBI）患者的一些全身和局部因素，包括细胞因子和生长因子，可能在加速骨折愈合中发挥重要作用。本研究的目的是评估一些炎症细胞因子和生长因子在骨折和创伤性脑损伤患者以及健康受试者的血清水平。本研究共招募股骨骨折患者30例，TBI患者30例，TBI合并股骨骨折患者30例（骨折+ TBI组），健康受试者30例。格拉斯哥昏迷量表（GCS）评分也在他们入院时确定。然后，通过酶联免疫吸附试验（ELISA）技术测定损伤后12小时和入院后4周血清成纤维细胞生长因子2 （FGF-2）、转化生长因子- β (tgf - β)、血小板源性生长因子（PDGF）、骨形态发生蛋白2 （BMP-2）、胰岛素样生长因子1 （IGF-1）、白细胞介素-1 β (IL-1 β)和白细胞介素-6 （IL-6）水平。研究结果显示，股骨骨折+ TBI组血清BMP-2、FGF-2、IL-1 β、PDGF水平在12 h及4周后均较其他组显著升高，但在12 h时血清IGF-I、IL-6、tgf - β水平较其他组显著升高。结果还显示，骨折+ TBI组股骨骨折愈合时间短于单纯股骨骨折组（p = 0.03）。因此，似乎血清中BMP-2、PDGF、FGF-2和IL-1 β水平的升高可能与骨折+ TBI患者的愈合加速有关。然而，需要进一步的研究来证实这一说法。
Evidence suggests that some systemic and local factors, including cytokines and growth factors in patients with traumatic brain injury (TBI), can play an essential role in accelerating fracture healing. The purpose of this study was to evaluate serum levels of some inflammatory cytokines and growth factors in patients with fracture and TBI as well as healthy subjects. In this study, a total number of 30 patients with a femoral fracture, 30 cases with TBI, 30 patients with TBI and a femoral fracture (fracture + TBI group), and 30 healthy subjects were recruited. The Glasgow Coma Scale (GCS) scores were also determined upon their admission. Then, the serum levels of fibroblast growth factor 2 (FGF-2), transforming growth factor-beta (TGF-beta), platelet-derived growth factor (PDGF), bone morphogenetic protein 2 (BMP-2), insulin-like growth factor 1 (IGF-1), interleukin-1 beta (IL-1 beta), and interleukin-6 (IL-6) were measured via enzyme-linked immunosorbent assay (ELISA) technique, 12 h and 4 weeks after injury and hospital admission. The study results demonstrated that the serum levels of BMP-2, FGF-2, IL-1 beta, and PDGF in the femoral fracture + TBI group increased significantly over 12 h and after 4 weeks compared with other groups, but the serum levels of IGF-I, IL-6, and TGF-beta in this group increased in a significant manner at 12 h compared with other studied groups. The findings also showed that the time to union of a femoral fracture was shorter in the fracture + TBI group than in cases with a femoral fracture alone (p = 0.03). Accordingly, it seems that elevated serum levels of BMP-2, PDGF, FGF-2, and IL-1 beta may be associated with healing acceleration in fracture + TBI patients. However, further studies are needed to confirm this claim.