High Ran level is correlated with poor prognosis in patients with colorectal cancer
High Ran level is correlated with poor prognosis in patients with colorectal cancer
复制标题
高 Ran 水平与结直肠癌患者不良预后相关
DOI：
10.1007/s10147-012-0465-x
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发表时间：
2013-10-01
影响因子：
3.3
通讯作者：
Fan, Daiming
中科院分区：
文献类型：
--
作者：
Fan, Hongwei;Lu, Yuanyuan;Fan, Daiming
Ras样核蛋白（Ras-like nuclear protein，Ran）参与细胞核运输、微管成核和动力学以及纺锤体组装的调控。其基本功能是RNA和蛋白质的核质转运。Ran在结直肠癌（CRC）中的表达和潜在作用尚不清楚。本研究的目的是探讨Ran表达与大肠癌特征的关系。Ran作为一个预后指标的潜在作用也evaluated.MethodsWe采用免疫组化和蛋白质印迹法检测Ran在287例结直肠癌组织中的表达。Ran表达与大肠癌临床病理特征及总生存率的关系进行统计学分析。RAN与浸润深度、淋巴结转移、远处转移、肿瘤分化程度、肿瘤淋巴结转移分期呈正相关。然而，Ran表达与患者的年龄和性别无关。Ran阳性肿瘤患者的总生存率始终显著低于Ran阴性tumors.ConclusionOur研究结果强调了Ran在人类结直肠癌分化、疾病分期和转移中的重要作用。RAN可能在结直肠癌的发生发展中起重要作用，并可能成为一种新的结直肠癌预后指标。
BackgroundThe Ras-like nuclear protein (Ran) is involved in the regulation of nuclear transport, microtubule nucleation and dynamics, and spindle assembly. Its fundamental function is nucleocytoplasmic transport of RNA and proteins. The expression and potential role of Ran in colorectal cancer (CRC) remain unclear. The aim of this study was to investigate the relationship between Ran expression and CRC characteristics. The potential role of Ran as a prognostic indicator was also evaluated.MethodsWe used immunohistochemistry and western blotting to detect Ran expression in 287 CRC tissues. The relationships between Ran expression and clinicopathological characteristics and overall survival rate were statistically analyzed.ResultsCRC tissues had significantly higher Ran expression than normal colorectal epithelial cells. Ran was positively correlated with depth of invasion, lymph node metastases, distant metastases, tumor differentiation, and tumor–node–metastasis stage. However, no correlation was found between Ran expression and patient age or sex. The overall survival rate was consistently and significantly lower in patients with Ran-positive tumors than in those with Ran-negative tumors.ConclusionOur findings emphasize the important role of Ran in differentiation, disease stage, and metastasis in human CRC. Ran may play an important role in the development of CRC and may serve as a novel prognostic indicator of CRC.