Age-related changes in monochromatic wave aberrations of the human eye.
Age-related changes in monochromatic wave aberrations of the human eye.
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DOI：
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发表时间：
2001-05
影响因子：
4.4
通讯作者：
J. S. McLellan;S. Marcos;S. Burns
中科院分区：
文献类型：
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作者：
J. S. McLellan;S. Marcos;S. Burns
目的探讨全眼光学像差与年龄的关系。如通过调制传递函数（MTF）测量的，眼睛的光学质量随着年龄而退化，但是MTF不提供评估个体像差（诸如彗差、球面像差和其他高阶像差）对光学质量变化的贡献的手段。本研究中使用的方法提供了个体像差和整体光学质量的测量。方法采用空间分辨折射仪对38名受试者进行了精神精神障碍性波像差测量。数据拟合Zernike多项式的第七阶，以提供35个单独的畸变项的估计。计算了调制传递函数和均方根波前误差。受试者年龄范围为22.9 - 64.5岁，等效球镜矫正范围为+0.5--6.0 D。结果：总体RMS波前误差（不包括倾斜、散光和散焦）与年龄显著正相关（r = 0.33，P = 0.042）。测量的最高阶像差的RMS误差（第五阶至第七阶）与年龄呈强正相关（r = 0.57，P = 0.0002）。图像质量，量化的MTF，也随着年龄的增长而下降。结论眼波像差随年龄增长而增大。这种增加与其他研究者观察到的对比敏感度随年龄的损失一致。
PURPOSE To investigate the relations between age and the optical aberrations of the whole eye. The eye's optical quality, as measured by the modulation transfer function (MTF), degrades with age, but the MTF does not provide a means to assess the contributions of individual aberrations, such as coma, spherical aberration, and other higher order aberrations to changes in optical quality. The method used in this study provides measures of individual aberrations and overall optical quality. METHODS Wave aberrations in 38 subjects were measured psychophysically using a spatially resolved refractometer. Data were fit with Zernike polynomials up to the seventh order to provide estimates of 35 individual aberration terms. MTFs and root mean square (RMS) wavefront errors were calculated. Subjects ranged in age from 22.9 to 64.5 years, with spherical equivalent corrections ranging from +0.5 to -6.0 D. RESULTS Overall RMS wavefront error (excluding tilts, astigmatism, and defocus) was significantly positively correlated with age (r = 0.33, P = 0.042). RMS error for the highest order aberrations measured (fifth through seventh order) showed a strong positive correlation with age (r = 0.57, P = 0.0002). Image quality, as quantified by the MTF, also degraded with age. CONCLUSIONS Wave aberrations of the eye increase with age. This increase is consistent with the loss of contrast sensitivity with age observed by other investigators.