Pharmacokinetics of Astragaloside IV in Rats by liquid chromatography coupled with tandem mass spectrometry
Pharmacokinetics of Astragaloside IV in Rats by liquid chromatography coupled with tandem mass spectrometry
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DOI：
10.1007/bf03190631
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发表时间：
2005-10-01
影响因子：
1.9
通讯作者：
Tu, CY
中科院分区：
文献类型：
--
作者：
Du, Y;Zhang, Q;Tu, CY
采用高效液相色谱-串联质谱法研究了黄芪甲苷在大鼠体内的药代动力学。静脉注射AGS-IV 1、2、4 mg/kg和po AGS-IV 20 mg/kg后测定血药浓度。AUC与剂量呈线性相关。静脉注射2 mg/kg后，分析胆汁、尿液和粪便中AGS-IV的回收率。胆汁中AGS-IV的累积回收率在24小时内达到30.8%。尿液和粪便中AGS-IV的累积回收率为52.14%，表明约50%的AGS-IV在体内被代谢。AGS-IV口服后的生物利用度为3.66%。这些发现为AGS-IV和其他潜在制剂的研究和开发提供了有用的信息。
Pharmacokinetics of Astragaloside IV (AGS-IV) in rats was studied by high performance liquid chromatography coupled with tandem mass spectrometry. The concentration in plasma was determined after iv administration of 1, 2, 4mg/kg and po administration of 20mg/kg of AGS-IV. The AUC were linearly correlated to doses. Recoveries of AGS-IV in bile, urine and feces were also analyzed following iv dose of 2 mg/kg. Cumulative recovery of AGS-IV in bile reached 30.8% in 24h. Cumulative recovery of AGS-IV in urine and feces was 52.14%, which indicates that about 50% of AGS-IV was metabolized in vivo. The bioavailability of AGS-IV after po administration was found to be 3.66%. These findings provide useful information for the research and development of AGS-IV and other potential agents.