Tunable Performance of Manganese Oxide Nanostructures as MRI Contrast Agents
Tunable Performance of Manganese Oxide Nanostructures as MRI Contrast Agents
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DOI：
10.1002/chem.201704861
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发表时间：
2018-01-26
影响因子：
4.3
通讯作者：
Gallo, Juan
中科院分区：
文献类型：
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作者：
Banobre-Lopez, Manuel;Garcia-Hevia, Lorena;Gallo, Juan
响应性磁共振成像造影剂的发展为改变的生理条件的高灵敏度和特异性诊断打开了大门。在这一领域，二氧化锰（MnO 2）由于其对与人类疾病状态相关的条件（如癌症）的敏感性而开始成为主要贡献者。到目前为止，二氧化锰的临床前应用主要是以纳米片的形式，激活后磁共振成像信号增强高达50倍。在这里，我们彻底调查，通过一个简单的反应，一系列的MnxOy样品和相关的相组成和结构/形态的性能作为经典的/响应的MRI造影剂在响应氧化还原的变化。从MnO 2纳米海胆中获得了高达140倍的信号增强，并在体外证明了它们作为响应性磁共振成像造影剂的能力。
The development of responsive magnetic resonance imaging contrast agents opens the door to a highly sensitive and specific diagnosis of altered physiological conditions. In this field, manganese dioxide (MnO2) is starting to be a leading contributor due to its susceptibility to conditions relevant to human diseased states, such as cancer. So far, the preclinical application of MnO2 has mainly been in the form of nanosheets, with enhancements of magnetic resonance imaging signals up to 50-fold upon activation. Herein, we thoroughly investigate, through a simple reaction, a series of MnxOy samples and correlate their phase composition and structure/morphology to the performance as classic/responsive MRI contrast agents in response to redox changes. Signal enhancements as high as 140-fold were obtained from MnO2 nano-urchins, and their capability as responsive magnetic resonance imaging contrast agents was demonstrated in vitro.