ABUSE POTENTIAL AND PHARMACOLOGICAL COMPARISON OF TRAMADOL AND MORPHINE
ABUSE POTENTIAL AND PHARMACOLOGICAL COMPARISON OF TRAMADOL AND MORPHINE
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DOI：
10.1016/0376-8716(91)90081-9
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发表时间：
1991-01-01
影响因子：
4.2
通讯作者：
TESTA, M
中科院分区：
文献类型：
--
作者：
PRESTON, KL;JASINSKI, DR;TESTA, M
该研究的目的是评估阿片类镇痛药曲马多的滥用可能性。 在志愿者非阿片类药物滥用者中进行肌肉注射测试曲马多（75、150 和 300 毫克）、吗啡（15 和 30 毫克）和安慰剂。 在给药前和给药后12小时内间歇性地评估主观、行为和缩瞳变化。 吗啡产生典型的主观效应、阿片类药物识别和瞳孔缩小。 75 毫克和 150 毫克曲马多与安慰剂没有差异。 尽管曲马多 300 毫克被鉴定为阿片类药物，但它不会产生其他类似吗啡的作用。 这些发现表明曲马多通过肠胃外途径滥用的可能性较低。
The purpose of the study was to assess the abuse potential of the opioid analgesic tramadol. Tramadol (75, 150 and 300 mg), morphine (15 and 30 mg) and placebo were tested intramuscularly in volunteer non-dependent opiate abusers. Subjective, behavioral and miotic changes were assessed prior to dosing and intermittently for 12 h after drug administration. Morphine produced typical subjective effects, opiate identifications and miosis. Tramadol 75 and 150 mg were not different from placebo. Although tramadol 300 mg was identified as an opiate, it produced no other morphine-like effects. These findings suggest that tramadol has a low abuse potential by the parenteral route.