The relationship between lung function and the clinical and histopathological features in Chinese patients with nasal polyps
The relationship between lung function and the clinical and histopathological features in Chinese patients with nasal polyps
复制标题
中国鼻息肉患者肺功能与临床及组织病理学特征的关系
DOI：
10.1017/s0022215117001657
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发表时间：
2017-10-01
影响因子：
1.7
通讯作者：
Zhang, H. P.
中科院分区：
文献类型：
--
作者：
Zhao, Q. L.;Yu, L.;Zhang, H. P.
摘要目的：探讨慢性鼻窦炎合并鼻息肉患者的肺功能及其与组织病理学特征的关系。方法：对99例鼻息肉患者进行肺功能测定。采用苏木精、伊红和免疫组化染色评价炎症细胞和上皮组织的重塑。结果：上皮细胞增生在25%肺活量时最大呼气流量的预测值降低（p < 0.05），杯状细胞增生在50%肺活量时最大呼气流量的预测值降低（p < 0.05）。外周血嗜酸性粒细胞和组织嗜酸性粒细胞鼻息肉均表现出明显降低：1秒用力呼气量/用力肺活量比，预测肺活量25%、50%和75%时最大呼气流量，预测最大呼气中流量。外周血嗜酸性粒细胞与肺活量25%和50%时预测最大呼气流量呈负相关，并与预测最大呼气中流量呈负相关。组织中嗜酸性粒细胞与除预测肺活量外的所有肺功能参数呈负相关。结论：临床医生应注意鼻息肉患者肺功能下降，尤其是嗜酸性粒细胞增多患者。
Abstract Objective: To investigate lung function in Chinese patients suffering from chronic rhinosinusitis with nasal polyps and examine its association with histopathological features. Methods: The lung function of 99 patients with nasal polyps was measured. Haematoxylin and eosin and immunohistochemistry staining were performed to evaluate any inflammatory cells and epithelial tissue remodelling. Results: Predicted maximal expiratory flow rate at 25 per cent vital capacity was reduced (p < 0.05) in epithelial hyperplasia, and predicted maximal expiratory flow rate at 50 per cent vital capacity was reduced (p < 0.05) in goblet cell hyperplasia. Both peripheral blood eosinophilia and tissue eosinophilia nasal polyps manifested significantly reduced: forced expiratory volume in 1 second/forced vital capacity ratio, predicted maximal expiratory flow rate at 25, 50 and 75 per cent of vital capacity, and predicted maximal mid-expiratory flow. Peripheral blood eosinophils were negatively correlated with predicted maximal expiratory flow rate at 25 and 50 per cent of vital capacity, and predicted maximal mid-expiratory flow. Eosinophils in tissue were negatively correlated with all lung function parameters investigated except predicted forced vital capacity. Conclusion: Clinicians should be aware of lung function decline in nasal polyps patients, especially in those with tissue eosinophilia.