In Vivo Modulation of Dendritic Cells by Engineered Materials: Towards New Cancer Vaccines.
In Vivo Modulation of Dendritic Cells by Engineered Materials: Towards New Cancer Vaccines.
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DOI：
10.1016/j.nantod.2011.08.005
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发表时间：
2011-10
期刊：
影响因子：
17.4
通讯作者：
Mooney DJ
中科院分区：
文献类型：
--
作者：
Kim J;Mooney DJ
治疗性癌症疫苗正在成为治疗癌症的新的和有效的方法。这些疫苗增强了机体对癌细胞的免疫反应，而树突状细胞（DC）是适应性免疫的启动子，是这些策略靶向的关键细胞类型。目前基于DC的癌症疫苗是基于细胞从患者分离后的离体操作，然后重新引入患者，但这种方法在实际癌症治疗中具有许多局限性。然而，材料科学的最新进展已经允许设计和制造可以特异性靶向体内DC的物理和化学功能化材料平台。这些材料，通过其在体内调节的DC，作为新的癌症治疗具有巨大的潜力。比DC小几个数量级的纳米颗粒可以通过被动或主动靶向有效地将抗原和危险信号传递给这些细胞。三维生物材料的尺寸比DC大几个数量级，创造了允许有效招募和编程这些细胞的微环境，并且可以用作靶向驻留DC的纳米颗粒的局部仓库。两种材料策略都显示出促进与治疗癌症相关的抗原特异性T细胞应答的潜力。
Therapeutic cancer vaccines are emerging as novel and potent approaches to treat cancer. These vaccines enhance the body’s immune response to cancerous cells, and dendritic cells (DCs), an initiator of adaptive immunity, are a key cell type targeted by these strategies. Current DC-based cancer vaccines are based on ex vivo manipulation of the cells following their isolation from the patient, followed by reintroduction to the patient, but this approach has many limitations in practical cancer treatment. However, recent progress in materials science has allowed the design and fabrication of physically and chemically functionalized materials platforms that can specifically target DCs in the body. These materials, through their in vivo modulation of DCs, have tremendous potentials as new cancer therapies. Nanoparticles, which are several orders of magnitude smaller than DCs, can efficiently deliver antigen and danger signals to these cells through passive or active targeting. Three-dimensional biomaterials, with sizes several orders of magnitude larger than DCs, create microenvironments that allow the effective recruitment and programming of these cells, and can be used as local depots of nanoparticles targeting resident DCs. Both material strategies have shown potential in promoting antigen-specific T cell responses of magnitudes relevant to treating cancer.
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影响因子：
--
作者：
Jähnisch H;Füssel S;Kiessling A;Wehner R;Zastrow S;Bachmann M;Rieber EP;Wirth MP;Schmitz M
通讯作者：
Schmitz M
影响因子：
4.4
作者：
Bourquin, Carole;Anz, David;Endres, Stefan
通讯作者：
Endres, Stefan
影响因子：
14
作者：
Hori, Yuki;Winans, Amy M.;Irvine, Darrell J.
通讯作者：
Irvine, Darrell J.
DOI：
10.1126/science.1171643
发表时间：
2009-06-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Discher DE;Mooney DJ;Zandstra PW
通讯作者：
Zandstra PW
影响因子：
4.7
作者：
Cheung, Wai-Hung;Chan, Vera Sau-Fong;Yu, Wing-Yiu
通讯作者：
Yu, Wing-Yiu