Increased apolipoprotein E epsilon 4 in epilepsy with senile plaques
Increased apolipoprotein E epsilon 4 in epilepsy with senile plaques
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DOI：
10.1002/ana.410410317
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发表时间：
1997-03-01
影响因子：
11.2
通讯作者：
Gandy, S
中科院分区：
文献类型：
--
作者：
Gouras, GK;Relkin, NR;Gandy, S
载脂蛋白 E (ApoE) epsilon 4 等位基因的遗传是阿尔茨海默病 (AD) 的危险因素，并且与 AD 中 β-淀粉样蛋白 (Aβ) 沉积的增加、唐氏综合症和正常衰老有关。最近在颞叶癫痫 (TLE) 患者中发现了老年斑 (SP) 形式的 β 沉积。我们研究了接受颞叶切除术治疗顽固性癫痫的患者的 ApoE epsilon 4 基因型与颞叶组织中 Aβ 沉积之间的关系。具有 SP 的 TLE 患者的 ApoE epsilon 4 携带频率为 70%，而年龄匹配的无 SP 的 TLE 对照的携带频率为 27%。我们的数据表明，ApoE ε 4 与脑内 A β 积累之间的关联并非老年人或痴呆症患者所独有，并且可能是同时存在 ApoE ε 4 等位基因和 A β 前体蛋白（可能还有 A β）过量产生的情况的一个特征。
Inheritance of the apolipoprotein E (ApoE) epsilon 4 allele is a risk factor for Alzheimer's disease (AD) and is associated with increased deposition of beta-amyloid (A beta) in AD, Down's syndrome, and normal aging. A beta deposition in the form of senile plaques (SPs) has recently been described in patients with temporal lobe epilepsy (TLE). We studied the relationship between ApoE epsilon 4 genotype and the deposition of A beta in temporal lobe tissue from patients who underwent temporal lobectomy for intractable epilepsy. TLE patients with SPs had a 70% ApoE epsilon 4 carrier frequency compared with a 27% carrier frequency among age-matched TLE controls without SPs. Our data suggest that the association between ApoE epsilon 4 and intracerebral A beta accumulation is not unique to the elderly or to those with dementia, and may be a feature of conditions in which there is both an ApoE epsilon 4 allele and overproduction of A beta precursor protein, and, presumably, A beta.