DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma
DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma
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DOI：
10.1093/neuonc/nop012
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发表时间：
2010-01-01
期刊：
影响因子：
15.9
通讯作者：
Inskip, Peter D.
中科院分区：
文献类型：
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作者：
Rajaraman, Preetha;Hutchinson, Amy;Inskip, Peter D.
虽然原发性脑肿瘤的病因在很大程度上是未知的，以前的研究表明，DNA修复多态性可能会影响神经胶质瘤的风险。改变的DNA修复也可能影响脑膜瘤和听神经瘤的风险，但这些肿瘤尚未得到很好的研究。在一项由美国国家癌症研究所开展的以医院为基础的病例对照研究中，我们评估了非西班牙裔白人患神经胶质瘤（n = 362）、脑膜瘤（n = 134）和听神经瘤（n = 69）的风险，这些风险与来自26个参与DNA修复基因的36个单核苷酸多态性有关。我们观察到GLTSCR 1 rs 1035938的T变体显著增加脑膜瘤的风险（ORCT/TT = 3.5; 95%置信区间：1.8-6.9; P趋势0.0006），在控制多重比较后持续存在（P = 0.019）。ERCC 4 rs 1800067（P趋势.01）、MUTYH rs3219466（P趋势.02）和PCNA rs 25406（P趋势.03）的次要等位基因变异也观察到脑膜瘤风险显著增加。NBN rs 1805794次要等位基因变异与脑膜瘤风险降低相关（P趋势0.006）。ERCC 2 rs 1799793（P趋势0.03）和ERCC 5 rs 17655（P趋势0.05）变异体的听神经瘤风险增加，PARP 1 rs 1136410（P趋势0.03）降低。用XRCC 1 rs 1799782变体观察到胶质瘤风险降低（P趋势.04）。我们的研究结果表明，常见的DNA修复变异可能会影响成人脑肿瘤的风险，特别是脑膜瘤。
Although the etiology of primary brain tumors is largely unknown, prior studies suggest that DNA repair polymorphisms may influence risk of glioma. Altered DNA repair is also likely to affect the risk of meningioma and acoustic neuroma, but these tumors have not been well studied. We estimated the risk of glioma (n = 362), meningioma (n = 134), and acoustic neuroma (n = 69) in non-Hispanic whites with respect to 36 single nucleotide polymorphisms from 26 genes involved in DNA repair in a hospital-based, case-control study conducted by the National Cancer Institute. We observed significantly increased risk of meningioma with the T variant of GLTSCR1 rs1035938 (ORCT/TT = 3.5; 95% confidence interval: 1.8-6.9; P-trend .0006), which persisted after controlling for multiple comparisons (P = .019). Significantly increased meningioma risk was also observed for the minor allele variants of ERCC4 rs1800067 (P-trend .01); MUTYH rs3219466 (P-trend .02), and PCNA rs25406 (P-trend .03). The NBN rs1805794 minor allele variant was associated with decreased meningioma risk (P-trend .006). Risk of acoustic neuroma was increased for the ERCC2 rs1799793 (P-trend .03) and ERCC5 rs17655 (P-trend .05) variants and decreased for the PARP1 rs1136410 (P-trend .03). Decreased glioma risk was observed with the XRCC1 rs1799782 variant (P-trend .04). Our results suggest that common DNA repair variants may affect the risk of adult brain tumors, especially meningioma.