APOE Effects on Late Life Cognitive Trajectories in Diverse Racial/Ethnic Groups.
APOE Effects on Late Life Cognitive Trajectories in Diverse Racial/Ethnic Groups.
复制标题
DOI：
10.1017/s1355617722000030
复制
发表时间：
2023-03
影响因子：
2.6
通讯作者：
Mungas, Dan
中科院分区：
文献类型：
--
作者：
Chan, Michelle L.;Meyer, Oanh L.;Farias, Sarah T.;Whitmer, Rachel A.;Rajan, Kumar;Olichney, John;Johnson, David;Mungas, Dan
这项研究评估了：1)黑人、拉丁裔和白人老年人中载脂蛋白Eε4的患病率，2)载脂蛋白Eε4状态与基线水平和跨组认知结果随时间变化的关系，以及3)载脂蛋白ε4患病率和影响程度对每个种族/民族组内认知功能下降的综合影响。参与者包括来自加州大学戴维斯分校纵向多样性队列的297名白人、138名拉丁裔和149名黑人，他们进行了载脂蛋白E基因分型和≥2认知评估。用多水平平行过程纵向分析和多组模型检验ε4与认知基线和跨种族/民族变化的关联程度。ε4在黑人(46%)和白人(46%)参与者中的患病率几乎是拉丁裔参与者(24%)的两倍。ε4只在白人参与者中与较差的基线情景记忆相关(p=0.001)，但在所有种族/民族中与情景记忆变化有中等强度的关联(黑人=−0.061 SD/年，拉丁裔=−0.055，白人=−0.055)。ε4与语义记忆变化的相关性在白人参与者中最强(−0.071)，在拉丁裔参与者中居中(−0.041)，在黑人参与者中最弱(−0.022)。计算的跨种族/民族群体的认知轨迹受到ε4患病率和组内认知下降关联强度的相加影响。ε-4患病率的群体差异以及ε-4与认知的关联可能表明，在非白人参与者中，从载脂蛋白E到认知下降的不同途径，AD对认知下降的影响可能不那么显著。载脂蛋白E对情景记忆和非记忆认知的不同影响对于理解载脂蛋白E是如何影响晚年认知衰退具有重要意义。
This study evaluated: 1)APOE ε4 prevalence among Black, Latino, and White older adults, 2)associations of APOE ε4 status with baseline level and change over time of cognitive outcomes across groups, and 3)combined impact of APOE ε4 prevalence and magnitude of effect on cognitive decline within each racial/ethnic group. Participants included 297 White, 138 Latino, 149 Black individuals from the longitudinal UC Davis Diversity Cohort who had APOE genotyping and ≥2 cognitive assessments. Magnitude of associations of ε4 with cognitive baseline and change across racial/ethnic groups was tested with multilevel parallel process longitudinal analyses and multiple group models. ε4 prevalence in Black (46%) and White participants (46%) was almost double that of Latino participants (24%). ε4 was associated with poorer baseline episodic memory only in White participants (p=0.001), but had a moderately strong association with episodic memory change across all racial/ethnic groups (Blacks=−0.061 SD/year, Latinos=− 0.055,Whites=−0.055). ε4 association with semantic memory change was strongest in White participants (−0.071), intermediate in Latino participants (−0.041), and weakest in Black participants (−0.022). Calculated cognitive trajectories across racial/ethnic groups were influenced in an additive manner by ε4 prevalence and strength of association with cognitive decline within the group. Group differences in ε4 prevalences and associations of ε4 with cognition may suggest different pathways from APOE to cognitive decline, and, AD possibly having less salient impact on cognitive decline in non-White participants. Differential effects of APOE on episodic memory and non-memory cognition have important implications for understanding how APOE influences late life cognitive decline.