Towards a bioelectronic computer: A theoretical study of a multi-layer biomolecular computing system that can process electronic inputs
Towards a bioelectronic computer: A theoretical study of a multi-layer biomolecular computing system that can process electronic inputs
复制标题
迈向生物电子计算机：可处理电子输入的多层生物分子计算系统的理论研究
DOI：
10.1101/290775
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Dunn K
中科院分区：
文献类型：
--
作者：
Dunn K
DNA分子机器在计算系统中具有巨大的应用潜力。自从Adleman最初通过使用DNA链来解决哈密顿路径问题而引入DNA计算的概念以来，一系列基于DNA的计算元件已经被开发出来，包括逻辑门、神经网络、有限状态机(FSM)和非确定性通用图灵机。DNA分子机器可以用电信号控制，DNA纳米设备的状态可以用电化学方法测量。然而，据我们所知，到目前为止还没有一个完全集成的生物分子计算系统具有多级信息处理能力，可以接受电子输入，并能够独立操作。在这里，我们讨论这样一个系统如何工作的问题。我们给出的模拟结果表明，这样一个集成的混合系统可以将电脉冲转换为生物分子信号，执行逻辑运算并做出决定，存储其历史。我们还从理论上说明了该系统如何能够控制一个自主机器人在迷宫中导航。我们的结果表明，所提出的类型的系统在技术上是可能的，但对于实际应用来说，将需要显著的进步来提高其速度。
DNA molecular machines have great potential for use in computing systems. Since Adleman originally introduced the concept of DNA computing through his use of DNA strands to solve a Hamiltonian path problem, a range of DNA-based computing elements have been developed, including logic gates, neural networks, finite state machines (FSMs) and non-deterministic universal Turing machines. DNA molecular machines can be controlled using electrical signals and the state of DNA nanodevices can be measured using electrochemical means. However, to the best of our knowledge there has as yet been no demonstration of a fully integrated biomolecular computing system that has multiple levels of information processing capacity, can accept electronic inputs and is capable of independent operation. Here we address the question of how such a system could work. We present simulation results showing that such an integrated hybrid system could convert electrical impulses into biomolecular signals, perform logical operations and take a decision, storing its history. We also illustrate theoretically how the system might be able to control an autonomous robot navigating through a maze. Our results suggest that a system of the proposed type is technically possible but for practical applications significant advances would be required to increase its speed.