Differences in motor learning success are associated with differences in M1 excitability
Differences in motor learning success are associated with differences in M1 excitability
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DOI：
10.1016/j.humov.2010.02.006
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发表时间：
2010-10-01
影响因子：
2.1
通讯作者：
Garry, Michael I.
中科院分区：
文献类型：
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作者：
Smyth, Carla;Summers, Jeff J.;Garry, Michael I.
初级运动皮层（M1）在运动学习中起作用，尽管其参与的确切性质尚不清楚。本研究通过对运动训练过程中增强反馈的操作，探讨了运动学习与皮质可塑性之间的关系。两组10名参与者进行腕屈伸波形跟踪任务，每次试验后并发和终端增强反馈（100% FB）或每次交替试验后仅终端反馈（50% FB）。采用单脉冲和双脉冲经颅磁刺激（TMS）在运动训练前、训练后和训练后24小时评估皮质兴奋性、短时间期皮质内抑制（SICI）和皮质内促进（ICF）。50%的FB组比100%的FB组在记忆方面表现得更好，这表明由于减少了FB时间安排，学习能力得到了提高。皮层兴奋性在习得过程中没有变化，然而，50% FB组在保留时M1兴奋性升高，这表明M1参与了学习巩固。练习后SICI的减少表明运动技能习得过程中皮质内抑制的减少。ICF不变。我们的结论是，与新运动技能的习得和保留相关的M1调制的性质似乎随着任务要求的性质和复杂性而变化。(C) 2010 Elsevier B.V.版权所有
Primary motor cortex (M1) plays a role in motor learning, although the exact nature of that involvement remains unclear. The present study examined the relationship between motor learning and cortical plasticity by manipulating augmented feedback during motor training. Two groups of 10 participants performed a wrist flexion-extension waveform-tracking task with either concurrent and terminal augmented feedback after every trial (100% FB) or only terminal feedback after every alternate trial (50% FB). Single- and paired-pulse transcranial magnetic stimulation (TMS) was used to assess cortical excitability short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) before, after, and 24 h following (retention) motor training. The 50% FB group performed better at retention than the 100% FB group, indicative of enhanced learning due to reduced FB scheduling. Cortical excitability did not change during acquisition for either group, however, the 50% FB group had elevated M1 excitability at retention, suggesting M1 involvement in the consolidation of learning. Reduced SICI following practice suggests a reduction of intracortical inhibition during motor skill acquisition. ICF was unchanged. It is concluded that the nature of M1 modulation associated with the acquisition and retention of a novel motor skill appears to vary with the nature and complexity of task requirements. (C) 2010 Elsevier B.V. All rights reserved.