NOVEL SKELETAL DRUG-DELIVERY SYSTEM USING SELF-SETTING CALCIUM-PHOSPHATE CEMENT .9. EFFECTS OF THE MIXING SOLUTION VOLUME ON ANTICANCER DRUG-RELEASE FROM HOMOGENEOUS DRUG-LOADED CEMENT
NOVEL SKELETAL DRUG-DELIVERY SYSTEM USING SELF-SETTING CALCIUM-PHOSPHATE CEMENT .9. EFFECTS OF THE MIXING SOLUTION VOLUME ON ANTICANCER DRUG-RELEASE FROM HOMOGENEOUS DRUG-LOADED CEMENT
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DOI：
10.1002/jps.2600840614
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发表时间：
1995-06-01
影响因子：
3.8
通讯作者：
HIGUCHI, WI
中科院分区：
文献类型：
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作者：
OTSUKA, M;MATSUDA, Y;HIGUCHI, WI
以抗癌剂6-巯基嘌呤(6-MP)为模型化合物，考察了混合液体积(0.25~0.65 mL/g)对自固化生物活性磷酸钙骨水泥体外释药的影响。在pH 7.25和37.0℃的模拟体液中，测量了含5%6-MP的水泥系统的孤立平面和整个表面的药物释放曲线。用Higuchi方程和Cobby方程分析了平面释放和全表面释放的骨水泥骨架系统的药物释放曲线，并用非线性最小二乘计算机程序估计了动力学参数。对于两种水泥释放几何形状，混合液体积与药物释放速率常数或药物释放50%所需时间之间存在线性关系。此外，用压汞法测得的水泥的总孔体积随着混合液体积的增加而增加。
The effects of mixing solution volume (0.25-0.65 mL/g) on in vitro drug release from a self-setting bioactive calcium phosphate cement containing the anticancer agent 6-mercaptopurine (6-MP) as a model compound were investigated. The drug release profiles from isolated planar surfaces as well as the entire surfaces of cement systems containing 5% 6-MP were measured in simulated body fluid at pH 7.25 and 37.0 degrees C. The drug release rate from both cement system geometries increased with increasing mixing solution volume. Drug release profiles from the planar-release and entire-surface-release cement matrix systems were analyzed by and found to agree with the Higuchi and Cobby equations, and the kinetic parameters were estimated with a nonlinear least-squares computer program. Linear relationships were found between the mixing solution volume and the drug release rate constants or time required for 50% drug release for both cement release geometries. Furthermore, the total pore volume of the cements, as measured by mercury porosimetry, increased with increasing mixing solution volume.