Do metastatic colorectal cancer patients who present with late relapse after curative surgery have a better survival?
Do metastatic colorectal cancer patients who present with late relapse after curative surgery have a better survival?
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DOI：
10.1038/bjc.2013.388
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发表时间：
2013-09-03
影响因子：
8.8
通讯作者：
Price, T. J.
中科院分区：
文献类型：
--
作者：
Broadbridge, V. T.;Karapetis, C. S.;Price, T. J.
背景：有治愈潜力的结直肠癌手术后复发的患者往往在5年内复发。然而，有一组患者在切除后5年以上复发，这组患者的行为和预后可能不同。方法：我们分析了一项基于人群的前瞻性登记数据，比较异时性mCRC复发患者的特征和生存期。患者在首次手术后5年复发。通过单因素log-rank检验和多因素Cox回归来确定复发时间（TTR）和其他因素是否与总生存期（OS）相关。结果：共发现750例异时性mCRC患者。总的来说，56%的患者在5年内复发。从诊断为mCRC开始，三组患者的中位生存时间分别为17.6个月、26.1个月和27.5个月。较短的TTR(5年vs
Background: Patients who relapse after potentially curative surgery for colorectal cancer tend to relapse within 5 years. There is, however, a group of patients who relapse beyond 5 years after resection and this late relapsing group may have a different behaviour and prognosis.Methods: We analysed data from a prospective population-based registry to compare the characteristics and survival of relapsed patients with metachronous mCRC. Patients were categorised into relapse at 5 years following their initial surgery. Univariate log-rank tests and multivariate Cox regression was performed to determine whether time to relapse (TTR) and other factors were associated with overall survival (OS).Results: A total of 750 metachronous mCRC patients were identified. In all, 56% relapsed 5 years. Median survival time from the time of diagnosis of mCRC for the three groups was 17.6, 26.1 and 27.5 months, respectively. Short TTR (5 years vs