Corneal sensitivity and subjective complaints of ocular pain in patients with fibromyalgia
Corneal sensitivity and subjective complaints of ocular pain in patients with fibromyalgia
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作者：
Aykut, V.;Elbay, A.;Oguz, H.
纤维肌痛（FM）是一种慢性疼痛障碍，与身体各部位的疼痛和过敏有关。本研究的目的是了解角膜敏感性的变化是否与这些患者的主观主诉有关。患者与方法本研究纳入36例FM患者（女性30例，男性6例，平均年龄46.7 +/- 9.2岁）和39例健康对照（女性33例，男性6例，平均年龄44.3 +/- 7.6岁）。我们进行了详细的眼科检查，测量泪膜破裂时间（TBUT），并进行了无麻醉Schirmer I试验（SIT）。只有没有任何眼病的患者被纳入这项研究。采用眼表疾病指数（OSDI）评分评价患者主观主诉，采用Cochet-Bonnet感觉仪评价患者角膜感觉。结果两组间年龄、性别、视力差异无统计学意义。FM组SIT （16.1 mm vs 15.3 mm， P=0.36）和TBUT结果（17.8 s vs 18.8 s， P=0.40）与对照组相似。然而，FM患者的角膜中央区（60.0 mm vs 55.0 mm， P=0.03）、上区（57.5 mm vs 50.0 mm， P=0.005）和下区（53.89 mm vs 46.03 mm, P < 0.001）的感觉明显增加。角膜感觉与OSDI评分呈显著正相关。结论：在本研究中，我们证实了FM患者的角膜敏感性增加，并有相关的眼表症状，类似于没有FM的干眼病。
Purpose Fibromyalgia (FM) is a chronic pain disorder associated with pain and hypersensitivity in various parts of the body. The aim of this study was to understand whether changes in corneal sensitivity were associated with the subjective complaints of these patients.Patients and methods In this study, we included 36 patients with FM (30 female, 6 male, mean age: 46.7 +/- 9.2 years) and 39 healthy control subjects (33 females, 6 males, mean age: 44.3 +/- 7.6 years). We performed a detailed ophthalmological examination, measured tear film breakup time (TBUT), and performed Schirmer I test without anesthetic (SIT). Only patients that did not have any eye disease were included in this study. Subjective complaints of the patients were evaluated with ocular surface disease index (OSDI) scores and the corneal sensation was evaluated with Cochet-Bonnet esthesiometer.Results There was no significant difference between the groups for age, sex, and visual acuity. Both SIT (16.1 mm vs 15.3 mm, P=0.36) and TBUT results (17.8 s vs 18.8 s, P=0.40) were similar in FM group and the controls subjects. However, corneal sensations in central (60.0 mm vs 55.0 mm, P=0.03), superior (57.5 mm vs 50.0 mm, P=0.005), and inferior (53.89 mm vs 46.03 mm, P < 0.001) regions were significantly increased in FM patients. There was a significant positive correlation between corneal sensation and OSDI scores.Conclusion In this study, we have demonstrated that the patients with FM have increased corneal sensitivity and have related ocular surface complaints similar to dry eye disease in the absence of it.