Ultradian oscillations of insulin secretion in humans
Ultradian oscillations of insulin secretion in humans
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DOI：
10.2337/diabetes.51.2007.s258
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发表时间：
2002-02-01
期刊：
影响因子：
7.7
通讯作者：
Brandenberger, G
中科院分区：
文献类型：
--
作者：
Simon, C;Brandenberger, G
超日节律似乎是几个内分泌系统的特征。如对其他激素所述，胰岛素释放是一个多振荡过程，具有约10分钟的快速脉冲和较慢的超日振荡（50-120分钟）。胰岛素分泌速率（ISR）的超昼夜节律振荡的机制尚未完全了解，其部分原因是快速脉冲的节律性放大。在人类中，同一周期范围内包括快速眼动（REM）和非REM（NREM）睡眠周期的交替以及交感迷走神经平衡中相关的相反振荡。在睡眠过程中，葡萄糖和ISR振荡放大了约150%，但REM-NREM睡眠周期并不携带葡萄糖和ISR超日振荡。此外，后者与交感神经平衡中的超昼夜振荡（从心脏R-R间期的光谱分析推断）或胰高血糖素样肽-1（GLP-1）（一种已知可增强葡萄糖刺激胰岛素的肠促胰岛素激素）的血浆波动无关。其他节律性的生理过程目前正在研究与超日胰岛素释放有关。糖尿病51（补编1）：S258-5261，2002年。
Ultradian rhythmicity appears to be characteristic of several endocrine systems. As described for other hormones, insulin release is a multioscillatory process with rapid pulses of about 10 min and slower ultradian oscillations (50-120 min). The mechanisms underlying the ultradian circhoral oscillations of insulin secretion rate (ISR), which arise in part from a rhythmic amplification of the rapid pulses, are not fully understood. In humans, included in the same period range is the alternation of rapid eye movement (REM) and non-REM (NREM) sleep cycles and the associated opposite oscillations in sympathovagal balance. During sleep, the glucose and ISR oscillations were amplified by about 150%, but the REM-NREM sleep cycles did not entrain the glucose and ISR ultradian oscillations. Also, the latter were not related to either the ultradian oscillations in sympathoagal balance, as inferred from spectral analysis of cardiac R-R intervals, or the plasma fluctuations of glucagon-like peptide-1 (GLP-1), an incretin hormone known to potentiate glucose-stimulated insulin. Other rhythmic physiological processes are currently being examined in relation to ultradian insulin release. Diabetes 51 (Suppl. 1):S258-5261, 2002.