A COMPARISON OF ILIAC BONE HISTOMORPHOMETRIC DATA IN POSTMENOPAUSAL OSTEOPOROTIC AND NORMAL SUBJECTS
A COMPARISON OF ILIAC BONE HISTOMORPHOMETRIC DATA IN POSTMENOPAUSAL OSTEOPOROTIC AND NORMAL SUBJECTS
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DOI：
10.1016/0169-6009(90)90061-j
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发表时间：
1990-11-01
期刊：
影响因子：
--
通讯作者：
ALOIA, JF
中科院分区：
文献类型：
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作者：
KIMMEL, DB;RECKER, RR;ALOIA, JF
对90例绝经后骨质疏松症妇女和34例健康绝经后妇女进行了活体荧光标记后的暂时性骨活检。标准的组织形态计量学数据来自未脱钙的切片。结构指数和重塑指数的值在每组中的分布是相同的。骨质疏松组骨体积减少35%(P<；0.001)，骨壁厚度减少12%(P<；0.001)，骨小梁厚度减少11%(P<；0.02)。骨质疏松症患者的骨小梁分离度增加34%(P<；0.001)，骨小梁数量减少36%(P<；0.001)。骨质疏松症患者活检中心宽度减少11%(P<；0.02)，皮质宽度减少35-50%(P<；0.001)。两组的改建、矿化表面和矿物沉积率的静态指标相似。两组的骨组织形态计量学变量的绝对值与大多数公布的数据相似。骨质疏松症患者的骨结构较差，骨小梁连接性明显降低，皮质变薄。重塑的动态指标无显著差异。由于组织形态计量学数据在两组中的分布相同，所以不存在非正常人群中的骨质疏松症受试者的特殊亚组。
Transilial bone biopsies following in vivo fluorochrome labeling were obtained from 90 women with postmenopausal osteoporosis and 34 healthy post-menopausal women. Standard histomorphometric data were collected from undecalcified sections. The distribution of values for both structural and remodelling indices was the same for each group. Bone volume was 35% lower (P < 0.001), wall thickness was 12% lower (P < 0.001), and trabecular thickness was 11% lower (P < 0.02) in osteoporotics. Trabecular separation was 34% greater (P < 0.001) and trabecular number was 36% lower (P < 0.001) in osteoporotics. Biopsy core width was 11% less (P < 0.02) and cortical width was 35-50% less (P < 0.001) in oosteoporotics. Static indices of remodelling, mineralizing surfaces, and mineral apposition rate were similar in the two groups. The absolute values for bone histomorphometric variables for both groups are similar to most published data. Osteoporotics had poorer bone structure, markedlyby decreased trabecular connectivity and thin cortices. There were no major differences in dynamic indices of remodelling. Since the histomorphometric data were distributed the same in both groups, special subsets of osteoporotic subjects not in the normal population did not exist.